2,8-Dimethyl-1,5-naphthyridine

Base Information

• Chemical Name: 2,8-Dimethyl-1,5-naphthyridine
• CAS No.: 764717-59-1
• Molecular Formula: C10H10 N2
• Molecular Weight: 158.1998
• DSSTox Substance ID: DTXSID40465351
• Wikidata: Q82291211
• Mol file: 764717-59-1.mol

Synonyms:2,8-dimethyl-1,5-naphthyridine;764717-59-1;1,5-Naphthyridine,2,8-dimethyl-;SCHEMBL7519332;DTXSID40465351;AKOS006330958

Chemical Property of 2,8-Dimethyl-1,5-naphthyridine

Chemical Property:

• PSA: 25.78000
• LogP: 2.24660
• XLogP3: 2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 158.084398327
• Heavy Atom Count: 12
• Complexity: 158

Purity/Quality:

97% ^*data from raw suppliers

2,8-Dimethyl-1,5-naphthyridine 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C2C(=NC=C1)C=CC(=N2)C

Technology Process of 2,8-Dimethyl-1,5-naphthyridine

There total 1 articles about 2,8-Dimethyl-1,5-naphthyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

3-amino-4-methylpyridine (3430-27-1) + acetaldehyde (75-07-0,9002-91-9) → 2,8-dimethyl[1,5]naphthyridine (764717-59-1)

Guidance literature:

With hydrogenchloride; for 1h; Heating;

DOI:10.1021/jm0400247

Reference yield:

2,8-dimethyl[1,5]naphthyridine (764717-59-1) → C17H12ClFN2O

Guidance literature:

With potassium hexamethylsilazane; In tetrahydrofuran; at -78 - 20 ℃; Inert atmosphere;

DOI:10.1016/j.bmc.2017.01.036

Reference yield:

2,8-dimethyl[1,5]naphthyridine (764717-59-1) → 4-(3-chloro-4-fluorophenyl)-5-(8-methyl-1,5-naphthyridin-2-yl)-1,3-thiazol-2-amine

Guidance literature:

Multi-step reaction with 3 steps

1: potassium hexamethylsilazane / tetrahydrofuran / -78 - 20 °C / Inert atmosphere

2: bromine / 1,4-dioxane / 1 h / 20 °C / Inert atmosphere

3: ethanol / Inert atmosphere; Reflux

With bromine; potassium hexamethylsilazane; In tetrahydrofuran; 1,4-dioxane; ethanol;

DOI:10.1016/j.bmc.2017.01.036

upstream raw materials:

3-amino-4-methylpyridine

acetaldehyde

Refernces