Technology Process of methyl 2-(2,2-dimethylcyclopentyl)-5'-(ethyIoxy)-2'-fluoro-1,1'-biphenyl-4-carboxylate
There total 10 articles about methyl 2-(2,2-dimethylcyclopentyl)-5'-(ethyIoxy)-2'-fluoro-1,1'-biphenyl-4-carboxylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen;
1% Pd/C;
In
methanol;
for 23h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium phosphate / 2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl; palladium diacetate / water; N,N-dimethyl-formamide / 21 h / 75 °C / Inert atmosphere
2.1: pyridinium p-toluenesulfonate / methanol / 19 h / 50 °C
3.1: dmap; triethylamine / dichloromethane / 0.33 h
3.2: 3 h / 20 °C
4.1: potassium carbonate / tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 21 h / 23 - 90 °C
5.1: hydrogen / palladium on activated charcoal / methanol / 23 h / 23 °C
With
dmap; potassium phosphate; hydrogen; pyridinium p-toluenesulfonate; potassium carbonate; triethylamine;
tetrakis(triphenylphosphine) palladium(0); 2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl; palladium on activated charcoal; palladium diacetate;
In
methanol; dichloromethane; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane / -78 °C
1.2: 18 h / -78 - 20 °C
2.1: potassium phenolate / bis-triphenylphosphine-palladium(II) chloride; triphenylphosphine / toluene / 2 h / 50 °C / Inert atmosphere
3.1: potassium phosphate / 2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl; palladium diacetate / water; N,N-dimethyl-formamide / 21 h / 75 °C / Inert atmosphere
4.1: pyridinium p-toluenesulfonate / methanol / 19 h / 50 °C
5.1: dmap; triethylamine / dichloromethane / 0.33 h
5.2: 3 h / 20 °C
6.1: potassium carbonate / tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 21 h / 23 - 90 °C
7.1: hydrogen / palladium on activated charcoal / methanol / 23 h / 23 °C
With
dmap; potassium phosphate; potassium phenolate; hydrogen; pyridinium p-toluenesulfonate; potassium carbonate; triethylamine; lithium diisopropyl amide;
bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium(0); 2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl; palladium on activated charcoal; palladium diacetate; triphenylphosphine;
In
tetrahydrofuran; methanol; n-heptane; dichloromethane; water; N,N-dimethyl-formamide; toluene;
