N-(4-{[(2-amino-4-oxo-1,4-dihydroquinazolin-6-yl)methyl]sulfanyl}benzoyl)glutamic acid

Base Information

Chemical Name:N-(4-{[(2-amino-4-oxo-1,4-dihydroquinazolin-6-yl)methyl]sulfanyl}benzoyl)glutamic acid
CAS No.:64088-74-0
Molecular Formula:C21H20 N4 O6 S
Molecular Weight:456.4717
Hs Code.:

Synonyms:L-Glutamicacid, N-[4-[[(2-amino-1,4-dihydro-4-oxo-6-quinazolinyl)methyl]thio]benzoyl]-(9CI); 10-Thia-5,8-dideazafolic acid; NCS 289523; NSC 289523

Suppliers and Price of N-(4-{[(2-amino-4-oxo-1,4-dihydroquinazolin-6-yl)methyl]sulfanyl}benzoyl)glutamic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 3 raw suppliers

Chemical Property of N-(4-{[(2-amino-4-oxo-1,4-dihydroquinazolin-6-yl)methyl]sulfanyl}benzoyl)glutamic acid

Chemical Property:

Density:1.55g/cm³

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of N-(4-{[(2-amino-4-oxo-1,4-dihydroquinazolin-6-yl)methyl]sulfanyl}benzoyl)glutamic acid

There total 7 articles about N-(4-{[(2-amino-4-oxo-1,4-dihydroquinazolin-6-yl)methyl]sulfanyl}benzoyl)glutamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 111718-86-6
di-tert-butyl 10-thia-5,8-dideazafolate

: 64088-74-0
10-thia-5,8-dideazafolic acid

Guidance literature:: With trifluoroacetic acid; for 1h;
DOI:10.1021/jm00397a031

Reference yield:

: 20057-83-4
diethyl 4,4'-dithiobis

: 64088-74-0
10-thia-5,8-dideazafolic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NaBH₄ / 1.) EtOH, 2.) DMF, 18 h

2: 73 percent / 0.2N NaOH / 45 h

3: 81 percent / (EtO)2P(O)CN, Et₃N / dimethylformamide / 1.5 h

4: 79 percent / CF₃CO₂H / 1 h

With sodium hydroxide; sodium tetrahydroborate; diethyl cyanophosphonate; triethylamine; trifluoroacetic acid; In N,N-dimethyl-formamide;
DOI:10.1021/jm00397a031

Reference yield:

: 32677-01-3
L-glutamic acid di-tert-butyl ester hydrochloride

: 64088-74-0
10-thia-5,8-dideazafolic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 81 percent / (EtO)2P(O)CN, Et₃N / dimethylformamide / 1.5 h

2: 79 percent / CF₃CO₂H / 1 h

With diethyl cyanophosphonate; triethylamine; trifluoroacetic acid; In N,N-dimethyl-formamide;
DOI:10.1021/jm00397a031