Technology Process of 14-(benzyloxy)morphinone
There total 4 articles about 14-(benzyloxy)morphinone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
14-benzyloxy-3-O-(triisopropyl)silylmorphinone;
With
hydrogenchloride;
In
methanol; water;
for 10h;
Reflux;
With
ammonium hydroxide;
In
water;
Alkaline aqueous solution;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 3.5 h / 20 °C / Inert atmosphere; Cooling with ice
2.1: formic acid; dihydrogen peroxide / water / 10 h / Cooling with ice
2.2: pH 10 - 11
3.1: sodium hydride / N,N-dimethyl-formamide; Petroleum ether / 0.83 h / 0 - 20 °C / Inert atmosphere; Cooling with ice bath
3.2: 3.67 h / -8 °C / Inert atmosphere; Cooling with ice /brine bath
4.1: hydrogenchloride / water; methanol / 10 h / Reflux
4.2: Alkaline aqueous solution
With
hydrogenchloride; formic acid; dihydrogen peroxide; sodium hydride; N-ethyl-N,N-diisopropylamine;
In
methanol; water; N,N-dimethyl-formamide; Petroleum ether;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: formic acid; dihydrogen peroxide / water / 10 h / Cooling with ice
1.2: pH 10 - 11
2.1: sodium hydride / N,N-dimethyl-formamide; Petroleum ether / 0.83 h / 0 - 20 °C / Inert atmosphere; Cooling with ice bath
2.2: 3.67 h / -8 °C / Inert atmosphere; Cooling with ice /brine bath
3.1: hydrogenchloride / water; methanol / 10 h / Reflux
3.2: Alkaline aqueous solution
With
hydrogenchloride; formic acid; dihydrogen peroxide; sodium hydride;
In
methanol; water; N,N-dimethyl-formamide; Petroleum ether;
