Technology Process of 14-benzyloxy-3-O-(triisopropyl)silylmorphinone
There total 4 articles about 14-benzyloxy-3-O-(triisopropyl)silylmorphinone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
14-hydroxy-3-O-(triisopropyl)silylmorphinone;
With
sodium hydride;
In
N,N-dimethyl-formamide; Petroleum ether;
at 0 - 20 ℃;
for 0.833333h;
Inert atmosphere;
Cooling with ice bath;
benzyl bromide;
In
N,N-dimethyl-formamide; Petroleum ether;
at -8 ℃;
for 3.67h;
Inert atmosphere;
Cooling with ice /brine bath;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 3.5 h / 20 °C / Inert atmosphere; Cooling with ice
2.1: formic acid; dihydrogen peroxide / water / 10 h / Cooling with ice
2.2: pH 10 - 11
3.1: sodium hydride / N,N-dimethyl-formamide; Petroleum ether / 0.83 h / 0 - 20 °C / Inert atmosphere; Cooling with ice bath
3.2: 3.67 h / -8 °C / Inert atmosphere; Cooling with ice /brine bath
With
formic acid; dihydrogen peroxide; sodium hydride; N-ethyl-N,N-diisopropylamine;
In
water; N,N-dimethyl-formamide; Petroleum ether;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 3.5 h / 20 °C / Inert atmosphere; Cooling with ice
2.1: formic acid; dihydrogen peroxide / water / 10 h / Cooling with ice
2.2: pH 10 - 11
3.1: sodium hydride / N,N-dimethyl-formamide; Petroleum ether / 0.83 h / 0 - 20 °C / Inert atmosphere; Cooling with ice bath
3.2: 3.67 h / -8 °C / Inert atmosphere; Cooling with ice /brine bath
With
formic acid; dihydrogen peroxide; sodium hydride; N-ethyl-N,N-diisopropylamine;
In
water; N,N-dimethyl-formamide; Petroleum ether;
