3-(4-benzyloxy-indol-3-yl)-2-nitro-5-oxa-hexanoic acid ethyl ester

Base Information

• Chemical Name: 3-(4-benzyloxy-indol-3-yl)-2-nitro-5-oxa-hexanoic acid ethyl ester
• CAS No.: 87824-18-8
• Molecular Formula: C₂₂H₂₄N₂O₆
• Molecular Weight: 412.442
• Mol file: 87824-18-8.mol

Synonyms:3-(4-benzyloxy-indol-3-yl)-2-nitro-5-oxa-hexanoic acid ethyl ester

Chemical Property of 3-(4-benzyloxy-indol-3-yl)-2-nitro-5-oxa-hexanoic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 3-(4-benzyloxy-indol-3-yl)-2-nitro-5-oxa-hexanoic acid ethyl ester

There total 1 articles about 3-(4-benzyloxy-indol-3-yl)-2-nitro-5-oxa-hexanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-benzyloxy-1H-indole (20289-26-3) + 4-methoxy-3-hydroxy-2-nitrobutyric acid ethyl ester (87824-17-7) → 3-(4-benzyloxy-indol-3-yl)-2-nitro-5-oxa-hexanoic acid ethyl ester (87824-18-8)

Guidance literature:

With acetic acid; In toluene; at 110 ℃; for 6.5h; toluene, 4 h, 110 deg C;

Reference yield: 81.0%

3-(4-benzyloxy-indol-3-yl)-2-nitro-5-oxa-hexanoic acid ethyl ester (87824-18-8) → 3-(4-benzyloxy-indole-3-yl)-2-amino-5-oxa-hexanoic acid ethyl ester (87824-19-9)

Guidance literature:

With hydrogen; nickel; In ethanol; at 25 ℃; for 1h; under 760 Torr;

Reference yield:

3-(4-benzyloxy-indol-3-yl)-2-nitro-5-oxa-hexanoic acid ethyl ester (87824-18-8) → ZK 91296 (83910-34-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 81 percent / hydrogen, Raney-Ni / ethanol / 1 h / 25 °C / 760 Torr

With hydrogen; nickel; In ethanol;

upstream raw materials:

4-benzyloxy-1H-indole

4-methoxy-3-hydroxy-2-nitrobutyric acid ethyl ester

Downstream raw materials:

3-(4-benzyloxy-indole-3-yl)-2-amino-5-oxa-hexanoic acid ethyl ester

ZK 91296