3-phenyl-2-(thiophen-2-yl)propanenitrile

Base Information

• Chemical Name: 3-phenyl-2-(thiophen-2-yl)propanenitrile
• CAS No.: 69347-49-5
• Molecular Formula: C₁₃H₁₁NS
• Molecular Weight: 213.303
• Mol file: 69347-49-5.mol

Synonyms:3-phenyl-2-(thiophen-2-yl)propanenitrile

Chemical Property of 3-phenyl-2-(thiophen-2-yl)propanenitrile

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 3-phenyl-2-(thiophen-2-yl)propanenitrile

There total 3 articles about 3-phenyl-2-(thiophen-2-yl)propanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

2-cyanomethylthiophene (20893-30-5) + benzyl alcohol (100-51-6,185532-71-2) → 3-phenyl-2-(thiophen-2-yl)propanenitrile (69347-49-5)

Guidance literature:

With 2,2':6,2''-terpyridine; bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; potassium carbonate; In tert-Amyl alcohol; at 150 ℃; for 5h; chemoselective reaction; Inert atmosphere;

DOI:10.1039/d1nj02243a

Reference yield: 29.0%

→ 3-phenyl-2-(thiophen-2-yl)propanenitrile (69347-49-5)

Guidance literature:

With C₄₉H₃₈Cl₂N₅O₄PRuS; potassium hydroxide; In toluene; at 140 ℃; for 4h; Inert atmosphere;

Reference yield:

2-cyanomethylthiophene (20893-30-5) + benzyl bromide (100-39-0) → 3-phenyl-2-(thiophen-2-yl)propanenitrile (69347-49-5)

Guidance literature:

2-cyanomethylthiophene; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 0.666667h;

benzyl bromide; In tetrahydrofuran; at -78 - 20 ℃; for 10h;

DOI:10.1055/s-0030-1258301

upstream raw materials:

2-cyanomethylthiophene

benzyl bromide

benzyl alcohol

Downstream raw materials:

C₁₄H₁₃NS

C₁₆H₁₅NS

C₁₇H₁₉NS