1-(3-chloro-4-(1-(5-ethylpyrimidin-2-yl)piperidin-4-yloxy)benzyl)piperazin-2-one

Base Information

Chemical Name:1-(3-chloro-4-(1-(5-ethylpyrimidin-2-yl)piperidin-4-yloxy)benzyl)piperazin-2-one
CAS No.:1190979-67-9
Molecular Formula:C₂₂H₂₈ClN₅O₂
Molecular Weight:429.95
Hs Code.:

Synonyms:1-(3-chloro-4-(1-(5-ethylpyrimidin-2-yl)piperidin-4-yloxy)benzyl)piperazin-2-one

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Chemical Property of 1-(3-chloro-4-(1-(5-ethylpyrimidin-2-yl)piperidin-4-yloxy)benzyl)piperazin-2-one

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Technology Process of 1-(3-chloro-4-(1-(5-ethylpyrimidin-2-yl)piperidin-4-yloxy)benzyl)piperazin-2-one

There total 10 articles about 1-(3-chloro-4-(1-(5-ethylpyrimidin-2-yl)piperidin-4-yloxy)benzyl)piperazin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1190979-66-8
N-tert-butyl 4-(3-chloro-4-(1-(5-ethylpyrimidin-2-yl)piperidin-4-yloxy)benzyl)-3-oxopiperazine-1-carboxylate

: 1190979-67-9
1-(3-chloro-4-(1-(5-ethylpyrimidin-2-yl)piperidin-4-yloxy)benzyl)piperazin-2-one

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 3964-58-7
3-chloro-4-hydroxybenzoic acid

: 1190979-67-9
1-(3-chloro-4-(1-(5-ethylpyrimidin-2-yl)piperidin-4-yloxy)benzyl)piperazin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: sulfuric acid / 3 h / Heating; Reflux

2.1: caesium carbonate / acetonitrile / 0.05 h / 180 °C / Microwave irradiation

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.17 h / 0 °C

4.1: methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C

5.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 60 °C

5.2: 12 h / 20 °C

6.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 1 h / 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; sulfuric acid; sodium hydride; caesium carbonate; methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 3964-57-6
methyl 4-hydroxy-3-chlorobenzoate

: 1190979-67-9
1-(3-chloro-4-(1-(5-ethylpyrimidin-2-yl)piperidin-4-yloxy)benzyl)piperazin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: caesium carbonate / acetonitrile / 0.05 h / 180 °C / Microwave irradiation

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.17 h / 0 °C

3.1: methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 60 °C

4.2: 12 h / 20 °C

5.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 1 h / 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; sodium hydride; caesium carbonate; methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;