N-tert-butyl 4-(3-chloro-4-(1-(5-ethylpyrimidin-2-yl)piperidin-4-yloxy)benzyl)-3-oxopiperazine-1-carboxylate

Base Information

Chemical Name:N-tert-butyl 4-(3-chloro-4-(1-(5-ethylpyrimidin-2-yl)piperidin-4-yloxy)benzyl)-3-oxopiperazine-1-carboxylate
CAS No.:1190979-66-8
Molecular Formula:C₂₇H₃₆ClN₅O₄
Molecular Weight:530.067
Hs Code.:

Synonyms:N-tert-butyl 4-(3-chloro-4-(1-(5-ethylpyrimidin-2-yl)piperidin-4-yloxy)benzyl)-3-oxopiperazine-1-carboxylate

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Chemical Property of N-tert-butyl 4-(3-chloro-4-(1-(5-ethylpyrimidin-2-yl)piperidin-4-yloxy)benzyl)-3-oxopiperazine-1-carboxylate

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Technology Process of N-tert-butyl 4-(3-chloro-4-(1-(5-ethylpyrimidin-2-yl)piperidin-4-yloxy)benzyl)-3-oxopiperazine-1-carboxylate

There total 9 articles about N-tert-butyl 4-(3-chloro-4-(1-(5-ethylpyrimidin-2-yl)piperidin-4-yloxy)benzyl)-3-oxopiperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1190979-65-7
2-(4-(2-chloro-4-(chloromethyl)phenoxy)piperidin-1-yl)-5-ethylpyrimidine

: 76003-29-7
4-(t-butyloxycarbonyl)piperazin-2-one

: 1190979-66-8
N-tert-butyl 4-(3-chloro-4-(1-(5-ethylpyrimidin-2-yl)piperidin-4-yloxy)benzyl)-3-oxopiperazine-1-carboxylate

Guidance literature:: 4-(t-butyloxycarbonyl)piperazin-2-one; With sodium hydride; In N,N-dimethyl-formamide; at 60 ℃; for 1h;

2-(4-(2-chloro-4-(chloromethyl)phenoxy)piperidin-1-yl)-5-ethylpyrimidine; In N,N-dimethyl-formamide; at 20 ℃; for 12h;

Reference yield:

: 3964-58-7
3-chloro-4-hydroxybenzoic acid

: 1190979-66-8
N-tert-butyl 4-(3-chloro-4-(1-(5-ethylpyrimidin-2-yl)piperidin-4-yloxy)benzyl)-3-oxopiperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sulfuric acid / 3 h / Heating; Reflux

2.1: caesium carbonate / acetonitrile / 0.05 h / 180 °C / Microwave irradiation

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.17 h / 0 °C

4.1: methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C

5.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 60 °C

5.2: 12 h / 20 °C

With lithium aluminium tetrahydride; sulfuric acid; sodium hydride; caesium carbonate; methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 5382-16-1
4-HYDROXYPIPERIDINE

: 1190979-66-8
N-tert-butyl 4-(3-chloro-4-(1-(5-ethylpyrimidin-2-yl)piperidin-4-yloxy)benzyl)-3-oxopiperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / ISOPROPYLAMIDE / 12 h / 150 °C

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

3.1: caesium carbonate / acetonitrile / 0.05 h / 180 °C / Microwave irradiation

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.17 h / 0 °C

5.1: methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C

6.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 60 °C

6.2: 12 h / 20 °C

With lithium aluminium tetrahydride; sodium hydride; potassium carbonate; caesium carbonate; methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; ISOPROPYLAMIDE; N,N-dimethyl-formamide; acetonitrile;