1-Bromomethyl-2,2-difluorocyclopropane

Base Information

• Chemical Name: 1-Bromomethyl-2,2-difluorocyclopropane
• CAS No.: 77613-65-1
• Molecular Formula: C4H5 Br F2
• Molecular Weight: 170.985
• Hs Code.: 2903890090
• European Community (EC) Number: 689-197-8
• DSSTox Substance ID: DTXSID80375748
• Mol file: 77613-65-1.mol

Synonyms:1-Bromomethyl-2,2-difluorocyclopropane;77613-65-1;2-(bromomethyl)-1,1-difluorocyclopropane;2,2-Difluorocyclopropylmethyl bromide;MFCD06797749;2-Bromomethyl-1,1-difluorocyclopropane;Cyclopropane, 2-(bromomethyl)-1,1-difluoro-;SCHEMBL348415;DTXSID80375748;bromomethyl-2,2-difluorocyclopropane;BBL102255;STL556054;AKOS005259623;AB29725;AT12585;FS-6233;1-Bromomethyl-2,2-difluoro-cyclopropane;2-(brornomethyl)-1,1-difluorocyclopropane;FT-0682938;EN300-305760;A839142;F2147-3965

Chemical Property of 1-Bromomethyl-2,2-difluorocyclopropane

Chemical Property:

• Boiling Point: 108-109°C
• PSA: 0.00000
• Density: 1.69g/ml
• LogP: 2.03650
• XLogP3: 2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 169.95427
• Heavy Atom Count: 7
• Complexity: 81.8

Purity/Quality:

98%min ^*data from raw suppliers

2-(bromomethyl)-1,1-difluorocyclopropane ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1C(C1(F)F)CBr

Technology Process of 1-Bromomethyl-2,2-difluorocyclopropane

There total 1 articles about 1-Bromomethyl-2,2-difluorocyclopropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.3%

→ 2-(bromomethyl)-1,1-difluorocyclopropane (77613-65-1)

Guidance literature:

Reference yield: 66.0%

2-(phenoxymethyl)-6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one (1382782-07-1) + 2-(bromomethyl)-1,1-difluorocyclopropane (77613-65-1) → 5-{[2,2-difluorocyclopropyl]methyl}-2-(phenoxymethyl)-6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one (1382782-33-3)

Guidance literature:

2-(phenoxymethyl)-6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one; With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃;

2-(bromomethyl)-1,1-difluorocyclopropane; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield: 25.0%

3-bromo-5-hydroxy-benzoic acid (140472-69-1) + 2-(bromomethyl)-1,1-difluorocyclopropane (77613-65-1) → (2,2-difluorocyclopropyl)methyl 3-bromo-5-[(2,2-difluorocyclopropyl)methoxy]benzoate

Guidance literature:

With potassium carbonate; In acetonitrile; at 60 ℃;

Downstream raw materials:

4-chloro-5-(2,2-difluorocyclopropylmethoxy)-2-fluoronitrobenzene

1-(6-{4-chloro-4'-[(2,2-difluorocyclopropyl)methoxy]-3'-methylbiphenyl-2-yl}pyridin-2-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

5-{[2,2-difluorocyclopropyl]methyl}-2-(phenoxymethyl)-6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one

N-((2S)-1-((2-(4-((2,2-difluorocyclopropyl)methoxy)-3-fluorophenyl)-7-fluoro-1,3-benzoxazol-6-yl)oxy)propan-2-yl)acetamide

Refernces