3-BROMO-5-HYDROXYBENZOIC ACID

Base Information

• Chemical Name: 3-BROMO-5-HYDROXYBENZOIC ACID
• CAS No.: 140472-69-1
• Molecular Formula: C7H5BrO3
• Molecular Weight: 217.019
• Hs Code.: 2918290000
• Mol file: 140472-69-1.mol

Synonyms:3-Bromo-5-hydroxybenzoicacid;

Chemical Property of 3-BROMO-5-HYDROXYBENZOIC ACID

Chemical Property:

• Vapor Pressure: 1.02E-06mmHg at 25°C
• Melting Point: 237-241 °C
• Refractive Index: 1.654
• Boiling Point: 388.1 °C at 760 mmHg
• PKA: 3.69±0.10(Predicted)
• Flash Point: 188.5 °C
• PSA: 57.53000
• Density: 1.861 g/cm³
• LogP: 1.85290
• Storage Temp.: Room temperature.
• Solubility.: soluble in Methanol

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Bromo-5-hydroxybenzoic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn,N
• Hazard Codes: Xn,N
• Statements: 22-50
• Safety Statements: 61

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-BROMO-5-HYDROXYBENZOIC ACID

There total 5 articles about 3-BROMO-5-HYDROXYBENZOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

3-bromo-5-iodo-benzoic acid (188815-32-9) → 3-bromo-5-hydroxy-benzoic acid (140472-69-1)

Guidance literature:

With sodium hydroxide; copper(I) oxide; In water; at 100 ℃; for 24h;

Reference yield: 66.0%

3-amino-5-bromobenzoic acid (42237-85-4) → 3-bromo-5-hydroxy-benzoic acid (140472-69-1)

Guidance literature:

With sulfuric acid; water; sodium nitrite; for 1.75h; Reflux;

Reference yield:

3-bromo-5-nitro-benzoic acid (6307-83-1) → 3-bromo-5-hydroxy-benzoic acid (140472-69-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogenchloride; tin(ll) chloride / ethanol; water / 2 h / 50 °C

1.2: pH 9

2.1: water; sodium nitrite; sulfuric acid / water / 1.75 h / Reflux

With hydrogenchloride; sulfuric acid; water; tin(ll) chloride; sodium nitrite; In ethanol; water;

upstream raw materials:

3-bromo-5-iodo-benzoic acid

3-amino-5-bromobenzoic acid

3-bromo-5-nitro-benzoic acid

3-nitrobenzoic acid

Downstream raw materials:

C₁₁H₁₄O₃

ethyl 3-bromo-5-ethoxybenzoate

2-(4-fluorophenyl)-5-(3-(isobutylcarbamoyl)-5-isopropoxyphenyl)-N-methylbenzofuran-3-carboxamide

3-bromo-N-isobutyl-5-isopropoxybenzamide

Refernces

• 1、 -. "3-(5-Amino-6-oxo-1,6-dihydropyridazin-3-yl)-biphenyl derivatives as PDE4 inhibitors". Page/Page column 23. . Retrieved 2012/01/03.
• 2、 -. "(3-oxo)pyridazin-4-ylurea derivatives as PDE4 inhibitors". Page/Page column 43. . Retrieved 2010/07/03.