N-benzyl-N-methyl-6,7,8,9,10,11-hexahydro-9-methyl-5,9:7,11-dimethano-5H-benzocyclononen-7-amine hydrochloride

Base Information

Chemical Name:N-benzyl-N-methyl-6,7,8,9,10,11-hexahydro-9-methyl-5,9:7,11-dimethano-5H-benzocyclononen-7-amine hydrochloride
CAS No.:1357114-96-5
Molecular Formula:C₂₄H₂₉N*ClH
Molecular Weight:367.962
Hs Code.:

Synonyms:N-benzyl-N-methyl-6,7,8,9,10,11-hexahydro-9-methyl-5,9:7,11-dimethano-5H-benzocyclononen-7-amine hydrochloride

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Chemical Property of N-benzyl-N-methyl-6,7,8,9,10,11-hexahydro-9-methyl-5,9:7,11-dimethano-5H-benzocyclononen-7-amine hydrochloride

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Technology Process of N-benzyl-N-methyl-6,7,8,9,10,11-hexahydro-9-methyl-5,9:7,11-dimethano-5H-benzocyclononen-7-amine hydrochloride

There total 4 articles about N-benzyl-N-methyl-6,7,8,9,10,11-hexahydro-9-methyl-5,9:7,11-dimethano-5H-benzocyclononen-7-amine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: N-benzyl-6,7,8,9,10,11-hexahydro-9-methyl-5,9:7,11-dimethano-5H-benzocyclononen-7-amine hydrochloride

: 1357114-96-5
N-benzyl-N-methyl-6,7,8,9,10,11-hexahydro-9-methyl-5,9:7,11-dimethano-5H-benzocyclononen-7-amine hydrochloride

Guidance literature:: formaldehyd; N-benzyl-6,7,8,9,10,11-hexahydro-9-methyl-5,9:7,11-dimethano-5H-benzocyclononen-7-amine hydrochloride; With sodium cyanoborohydride; acetic acid; In water; acetonitrile; at 20 ℃; for 4.5h;

With sodium hydroxide; In water;

With hydrochloric acid diethyl ether; In ethyl acetate;
DOI:10.1016/j.bmc.2011.11.050

Reference yield:

: 73947-11-2
7,11-dimethylene-6,7,8,9-tetrahydro-5,9-propano-5H-benzocycloheptene

: 1357114-96-5
N-benzyl-N-methyl-6,7,8,9,10,11-hexahydro-9-methyl-5,9:7,11-dimethano-5H-benzocyclononen-7-amine hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: sulfuric acid; acetic acid / 0 - 20 °C

2: acetic acid; thiourea / ethanol / 18 h / Reflux

3: sodium cyanoborohydride; acetic acid / methanol / 18 h / 20 °C

4: sodium cyanoborohydride; acetic acid / water; acetonitrile / 4.5 h / 20 °C

With sulfuric acid; sodium cyanoborohydride; acetic acid; thiourea; In methanol; ethanol; water; acetonitrile; 1: Ritter type transannular cyclization;
DOI:10.1016/j.bmc.2011.11.050

Reference yield:

: 1357114-93-2
2-chloro-N-(9-methyl-5,6,8,9,10,11-hexahydro-7H-5,9:7,11-dimethanobenzo[9]annulen-7-yl)acetamide

: 1357114-96-5
N-benzyl-N-methyl-6,7,8,9,10,11-hexahydro-9-methyl-5,9:7,11-dimethano-5H-benzocyclononen-7-amine hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid; thiourea / ethanol / 18 h / Reflux

2: sodium cyanoborohydride; acetic acid / methanol / 18 h / 20 °C

3: sodium cyanoborohydride; acetic acid / water; acetonitrile / 4.5 h / 20 °C

With sodium cyanoborohydride; acetic acid; thiourea; In methanol; ethanol; water; acetonitrile;
DOI:10.1016/j.bmc.2011.11.050