(2S,3R)-3-(furan-2-yl)-3-(4-methoxybenzyloxy)-2-methylpropanal

Base Information

• Chemical Name: (2S,3R)-3-(furan-2-yl)-3-(4-methoxybenzyloxy)-2-methylpropanal
• CAS No.: 1071850-36-6
• Molecular Formula: C₁₆H₁₈O₄
• Molecular Weight: 274.317
• Mol file: 1071850-36-6.mol

Synonyms:(2S,3R)-3-(furan-2-yl)-3-(4-methoxybenzyloxy)-2-methylpropanal

Chemical Property of (2S,3R)-3-(furan-2-yl)-3-(4-methoxybenzyloxy)-2-methylpropanal

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of (2S,3R)-3-(furan-2-yl)-3-(4-methoxybenzyloxy)-2-methylpropanal

There total 1 articles about (2S,3R)-3-(furan-2-yl)-3-(4-methoxybenzyloxy)-2-methylpropanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(2R,3R)-3-(furan-2-yl)-3-(4-methoxybenzyloxy)-2-methylpropan-1-ol (1071850-34-4) → (2S,3R)-3-(furan-2-yl)-3-(4-methoxybenzyloxy)-2-methylpropanal (1071850-36-6)

Guidance literature:

With sulfur trioxide pyridine complex; dimethyl sulfoxide; triethylamine; In dichloromethane; at 0 ℃; for 0.75h; Inert atmosphere;

DOI:10.1002/anie.200802079

Reference yield: 79.0%

(2S,3R)-3-(furan-2-yl)-3-(4-methoxybenzyloxy)-2-methylpropanal (1071850-36-6) + (Z )-3-iodo-1-triisopropylsiloxy-2-butene (153109-53-6) → (1R,2R,3R,Z)-1-(furan-2-yl)-1-(4-methoxybenzyloxy)-2,4-dimethyl-6-(triisopropylsiloxy)hex-4-en-3-ol (1071850-38-8)

Guidance literature:

(Z )-3-iodo-1-triisopropylsiloxy-2-butene; With tert.-butyl lithium; In tetrahydrofuran; pentane; at -78 ℃; for 1h; Inert atmosphere;

With dimethyl zinc(II); In tetrahydrofuran; hexane; pentane; at -78 - 0 ℃; Inert atmosphere;

(2S,3R)-3-(furan-2-yl)-3-(4-methoxybenzyloxy)-2-methylpropanal; In tetrahydrofuran; hexane; pentane; at -78 - -35 ℃; for 3h; diastereoselective reaction; Inert atmosphere;

DOI:10.1002/anie.200802079

upstream raw materials:

(2R,3R)-3-(furan-2-yl)-3-(4-methoxybenzyloxy)-2-methylpropan-1-ol

Downstream raw materials:

(1R,2R,3R,Z)-1-(furan-2-yl)-1-(4-methoxybenzyloxy)-2,4-dimethyl-6-(triisopropylsiloxy)hex-4-en-3-ol