(1R,2R,3R,Z)-1-(furan-2-yl)-1-(4-methoxybenzyloxy)-2,4-dimethyl-6-(triisopropylsiloxy)hex-4-en-3-ol

Base Information

• Chemical Name: (1R,2R,3R,Z)-1-(furan-2-yl)-1-(4-methoxybenzyloxy)-2,4-dimethyl-6-(triisopropylsiloxy)hex-4-en-3-ol
• CAS No.: 1071850-38-8
• Molecular Formula: C₂₉H₄₆O₅Si
• Molecular Weight: 502.767
• Mol file: 1071850-38-8.mol

Synonyms:(1R,2R,3R,Z)-1-(furan-2-yl)-1-(4-methoxybenzyloxy)-2,4-dimethyl-6-(triisopropylsiloxy)hex-4-en-3-ol

Chemical Property of (1R,2R,3R,Z)-1-(furan-2-yl)-1-(4-methoxybenzyloxy)-2,4-dimethyl-6-(triisopropylsiloxy)hex-4-en-3-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,2R,3R,Z)-1-(furan-2-yl)-1-(4-methoxybenzyloxy)-2,4-dimethyl-6-(triisopropylsiloxy)hex-4-en-3-ol

There total 1 articles about (1R,2R,3R,Z)-1-(furan-2-yl)-1-(4-methoxybenzyloxy)-2,4-dimethyl-6-(triisopropylsiloxy)hex-4-en-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

(2S,3R)-3-(furan-2-yl)-3-(4-methoxybenzyloxy)-2-methylpropanal (1071850-36-6) + (Z )-3-iodo-1-triisopropylsiloxy-2-butene (153109-53-6) → (1R,2R,3R,Z)-1-(furan-2-yl)-1-(4-methoxybenzyloxy)-2,4-dimethyl-6-(triisopropylsiloxy)hex-4-en-3-ol (1071850-38-8)

Guidance literature:

(Z )-3-iodo-1-triisopropylsiloxy-2-butene; With tert.-butyl lithium; In tetrahydrofuran; pentane; at -78 ℃; for 1h; Inert atmosphere;

With dimethyl zinc(II); In tetrahydrofuran; hexane; pentane; at -78 - 0 ℃; Inert atmosphere;

(2S,3R)-3-(furan-2-yl)-3-(4-methoxybenzyloxy)-2-methylpropanal; In tetrahydrofuran; hexane; pentane; at -78 - -35 ℃; for 3h; diastereoselective reaction; Inert atmosphere;

DOI:10.1002/anie.200802079

Reference yield: 99.0%

(1R,2R,3R,Z)-1-(furan-2-yl)-1-(4-methoxybenzyloxy)-2,4-dimethyl-6-(triisopropylsiloxy)hex-4-en-3-ol (1071850-38-8) + triisopropylsilyl trifluoromethanesulfonate (80522-42-5) → (1R,2S,3R,Z)-1-(furan-2-yl)-1-(4-methoxybenzyloxy)-2,4-dimethyl-3,6-bis(triisopropylsiloxy)hex-4-ene (1071850-40-2)

Guidance literature:

With 2,6-dimethylpyridine; In dichloromethane; at 0 ℃; for 23h; Inert atmosphere;

DOI:10.1002/anie.200802079

upstream raw materials:

(2S,3R)-3-(furan-2-yl)-3-(4-methoxybenzyloxy)-2-methylpropanal

(Z )-3-iodo-1-triisopropylsiloxy-2-butene

Downstream raw materials:

(1R,2S,3R,Z)-1-(furan-2-yl)-1-(4-methoxybenzyloxy)-2,4-dimethyl-3,6-bis(triisopropylsiloxy)hex-4-ene