Boc-L-6-hydroxynorleucine

Base Information

• Chemical Name: Boc-L-6-hydroxynorleucine
• CAS No.: 77611-37-1
• Molecular Formula: C11H21 N O5
• Molecular Weight: 247.291
• Hs Code.: 2924199090
• DSSTox Substance ID: DTXSID10463788
• Wikidata: Q82288824
• Mol file: 77611-37-1.mol

Synonyms:BOC-L-6-HYDROXYNORLEUCINE;77611-37-1;(S)-2-((tert-Butoxycarbonyl)amino)-6-hydroxyhexanoic acid;Boc-L-Nle(6-OH)-OH;(2S)-6-hydroxy-2-[(2-methylpropan-2-yl)oxycarbonylamino]hexanoic Acid;(S)-2-(tert-butoxycarbonylamino)-6-hydroxyhexanoic acid;N-alpha-t-Butyloxycarbonyl-6-hydroxy-L-norleucine;MFCD01862292;L-Norleucine, N-[(1,1-dimethylethoxy)carbonyl]-6-hydroxy-;SCHEMBL788895;DTXSID10463788;BRFDKSWARKFUGQ-QMMMGPOBSA-N;AKOS015948742;N-t-butoxycarbonyl-6-hydroxynorleucine;Boc-L-6-hydroxynorleucine, AldrichCPR;GS-6161;(S)-2-(Boc-amino)-6-hydroxyhexanoic acid;CS-0179118;H10457;A865188;(S)-2-tert-butoxycarbonylamino-6-hydroxy-hexanoic acid;(2S)-2-{[(tert-butoxy)carbonyl]amino}-6-hydroxyhexanoic acid

Chemical Property of Boc-L-6-hydroxynorleucine

Chemical Property:

• Melting Point: 110-112°C
• Boiling Point: 421.7±40.0 °C(Predicted)
• PKA: 3.98±0.21(Predicted)
• PSA: 95.86000
• Density: 1.150±0.06 g/cm3(Predicted)
• LogP: 1.51780
• Storage Temp.: 2-8°C
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 8
• Exact Mass: 247.14197277
• Heavy Atom Count: 17
• Complexity: 259

Purity/Quality:

97% ^*data from raw suppliers

Boc-L-6-hydroxynorleucine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)NC(CCCCO)C(=O)O
• Isomeric SMILES: CC(C)(C)OC(=O)N[C@@H](CCCCO)C(=O)O

Technology Process of Boc-L-6-hydroxynorleucine

There total 14 articles about Boc-L-6-hydroxynorleucine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

→ (S)-2-((tert-butoxycarbonyl)amino)-6-hydroxyhexanoic acid (77611-37-1)

Guidance literature:

Reference yield: 88.0%

(S)-2-amino-6-hydroxyhexanoic acid (6033-32-5) + di-tert-butyl dicarbonate (24424-99-5) → (S)-2-((tert-butoxycarbonyl)amino)-6-hydroxyhexanoic acid (77611-37-1)

Guidance literature:

With triethylamine; In tetrahydrofuran; water; for 6h;

DOI:10.1134/S1068162008060034

Reference yield: 80.0%

di-tert-butyl dicarbonate (24424-99-5) → (S)-2-((tert-butoxycarbonyl)amino)-6-hydroxyhexanoic acid (77611-37-1)

Guidance literature:

With triethylamine; In tetrahydrofuran; water; at 20 ℃;

upstream raw materials:

(S)-2-amino-6-hydroxyhexanoic acid

di-tert-butyl dicarbonate

Boc-Lys-OH

N^α-(tert-butoxycarbonyl)-L-α-aminoadipic acid

Downstream raw materials:

(2S)-[(2S)-((2S)-tert-butoxycarbonylamino-6-hydroxyhexanoylamino)-3-methyl-butyrylamino]-3-(4-hydroxyphenyl)propionic acid methyl ester

(2S)-[(2S)-((2S)-tert-butoxycarbonylamino-6-hydroxyhexanoylamino)hexanoylamino]-3-(4-hydroxyphenyl)propionic acid methyl ester

(2S)-[(2S)-((2S)-tert-butoxycarbonylamino-6-hydroxyhexanoylamino)-3-propoxy-propionylamino]-3-(4-hydroxy-phenyl)propionic acid methyl ester

(1-Benzyloxycarbamoyl-5-hydroxy-pentyl)-carbamic acid tert-butyl ester