L-N-Boc-ε-hydroxynorleucine benzylhydroxamate

Base Information

Chemical Name:L-N-Boc-ε-hydroxynorleucine benzylhydroxamate
CAS No.:77611-38-2
Molecular Formula:C₁₈H₂₈N₂O₅
Molecular Weight:352.431
Hs Code.:

Synonyms:L-N-Boc-ε-hydroxynorleucine benzylhydroxamate

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Chemical Property of L-N-Boc-ε-hydroxynorleucine benzylhydroxamate

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Technology Process of L-N-Boc-ε-hydroxynorleucine benzylhydroxamate

There total 4 articles about L-N-Boc-ε-hydroxynorleucine benzylhydroxamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 2687-43-6
O-benzylhydoxylamine hydrochloride

: 77611-37-1
(S)-2-((tert-butoxycarbonyl)amino)-6-hydroxyhexanoic acid

: 77611-38-2
L-N-Boc-ε-hydroxynorleucine benzylhydroxamate

Guidance literature:: With sodium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In water; for 0.75h;
DOI:10.1021/ja00340a017

Reference yield: 80.0%

: 2687-43-6
O-benzylhydoxylamine hydrochloride

: 77611-37-1,81505-64-8
α-N-(tert-butoxycarbonyl)-L-ε-hydroxynorleucine

: 77611-38-2,84063-93-4
(1-Benzyloxycarbamoyl-5-hydroxy-pentyl)-carbamic acid tert-butyl ester

Guidance literature:: With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In water; for 0.5h; Ambient temperature; pH 4.5;
DOI:10.1021/jo00326a061

Reference yield:

: 5462-80-6
rac-6-hydroxynorleucine

: 77611-38-2,84063-93-4
(1-Benzyloxycarbamoyl-5-hydroxy-pentyl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 76 percent

2: 80 percent / Et₃N / tetrahydrofuran; H₂O / Ambient temperature; overnight

3: 80 percent / 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide / H₂O / 0.5 h / Ambient temperature; pH 4.5

With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In tetrahydrofuran; water;
DOI:10.1021/jo00326a061