(S)-2-Amino-3-(4-(trifluoromethoxy)phenyl)propanoic acid hydrochloride

Base Information

• Chemical Name: (S)-2-Amino-3-(4-(trifluoromethoxy)phenyl)propanoic acid hydrochloride
• CAS No.: 921609-34-9
• Molecular Formula: C₁₀H₁₀F₃NO₃*ClH
• Molecular Weight: 285.65
• Mol file: 921609-34-9.mol

Synonyms:(2S)-2-amino-3-[4-(trifluoromethoxy)phenyl]propanoic acid hydrochloride

Chemical Property of (S)-2-Amino-3-(4-(trifluoromethoxy)phenyl)propanoic acid hydrochloride

Chemical Property:

• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

95+% ^*data from raw suppliers

H-L-Phe(4-OCF3)-OH ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-Amino-3-(4-(trifluoromethoxy)phenyl)propanoic acid hydrochloride

There total 6 articles about (S)-2-Amino-3-(4-(trifluoromethoxy)phenyl)propanoic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

methyl (2S)-2-(acetylamino)-3-[4-(trifluoromethoxy)phenyl]propanoate (921623-42-9) → (2S)-2-amino-3-[4-(trifluoromethoxy)phenyl]propanoic acid hydrochloride (921609-34-9,1810074-80-6)

Guidance literature:

With hydrogenchloride; water; at 100 ℃; for 4h; Product distribution / selectivity;

Reference yield: 60.0%

tert-butyl (2S)-2-[(diphenylmethylene)amino]-3-[4-(trifluoromethoxy)phenyl]propanoate → (2S)-2-amino-3-[4-(trifluoromethoxy)phenyl]propanoic acid hydrochloride (921609-34-9,1810074-80-6)

Guidance literature:

With hydrogenchloride; water; for 3h; Product distribution / selectivity; Heating / reflux;

Reference yield:

2-methyl-4-[4-(trifluoromethoxy)benzylidene]-1,3-oxazol-5(4H)-one → (2S)-2-amino-3-[4-(trifluoromethoxy)phenyl]propanoic acid hydrochloride (921609-34-9,1810074-80-6)

Guidance literature:

Multi-step reaction with 4 steps

1: methanol / 4 h / 20 - 60 °C

2: hydrogen / palladium 10% on activated carbon / 2 h / 20 °C

3: CHIRALPAK AD-H / ethanol; hexane / 20 °C / Resolution of racemate

4: hydrogenchloride; water / 4 h / 100 °C

With hydrogenchloride; water; hydrogen; palladium 10% on activated carbon; In methanol; ethanol; hexane;

upstream raw materials:

methyl (2S)-2-(acetylamino)-3-[4-(trifluoromethoxy)phenyl]propanoate

Methyl 2-(acetylamino)-3-[4-(trifluoromethoxy)phenyl]propanoate

C₁₃H₁₂F₃NO₄

p-trifluoromethoxybenzaldehyde

Downstream raw materials:

2-({(2S)-2-amino-3-[4-(trifluoromethoxy)phenyl]propanoyl}amino)ethyl acetate

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