2-({(2S)-2-amino-3-[4-(trifluoromethoxy)phenyl]propanoyl}amino)ethyl acetate

Base Information

Chemical Name:2-({(2S)-2-amino-3-[4-(trifluoromethoxy)phenyl]propanoyl}amino)ethyl acetate
CAS No.:921605-11-0
Molecular Formula:C₁₄H₁₇F₃N₂O₄
Molecular Weight:334.295
Hs Code.:

Synonyms:2-({(2S)-2-amino-3-[4-(trifluoromethoxy)phenyl]propanoyl}amino)ethyl acetate

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Chemical Property of 2-({(2S)-2-amino-3-[4-(trifluoromethoxy)phenyl]propanoyl}amino)ethyl acetate

Chemical Property:

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Technology Process of 2-({(2S)-2-amino-3-[4-(trifluoromethoxy)phenyl]propanoyl}amino)ethyl acetate

There total 4 articles about 2-({(2S)-2-amino-3-[4-(trifluoromethoxy)phenyl]propanoyl}amino)ethyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 921623-42-9
methyl (2S)-2-(acetylamino)-3-[4-(trifluoromethoxy)phenyl]propanoate

: 921605-11-0
2-({(2S)-2-amino-3-[4-(trifluoromethoxy)phenyl]propanoyl}amino)ethyl acetate

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride; water / 4 h / 100 °C

2: sodium hydroxide / water / 1.17 h / 0 - 20 °C

3: diethyl cyanophosphonate; triethylamine / N,N-dimethyl-formamide / 3.75 h / 0 - 20 °C

4: hydrogen bromide; acetic acid / 4 h / 0 - 20 °C

With hydrogenchloride; sodium hydroxide; diethyl cyanophosphonate; water; hydrogen bromide; acetic acid; triethylamine; In water; N,N-dimethyl-formamide; 3: Schotten-Baumann Reaction;

Reference yield:

: 921609-34-9,1810074-80-6
(2S)-2-amino-3-[4-(trifluoromethoxy)phenyl]propanoic acid hydrochloride

: 921605-11-0
2-({(2S)-2-amino-3-[4-(trifluoromethoxy)phenyl]propanoyl}amino)ethyl acetate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / water / 1.17 h / 0 - 20 °C

2: diethyl cyanophosphonate; triethylamine / N,N-dimethyl-formamide / 3.75 h / 0 - 20 °C

3: hydrogen bromide; acetic acid / 4 h / 0 - 20 °C

With sodium hydroxide; diethyl cyanophosphonate; hydrogen bromide; acetic acid; triethylamine; In water; N,N-dimethyl-formamide; 2: Schotten-Baumann Reaction;

Reference yield:

: 174732-83-3
Methyl 2-(acetylamino)-3-[4-(trifluoromethoxy)phenyl]propanoate

: 921605-11-0
2-({(2S)-2-amino-3-[4-(trifluoromethoxy)phenyl]propanoyl}amino)ethyl acetate

Guidance literature:: Multi-step reaction with 5 steps

1: CHIRALPAK AD-H / ethanol; hexane / 20 °C / Resolution of racemate

2: hydrogenchloride; water / 4 h / 100 °C

3: sodium hydroxide / water / 1.17 h / 0 - 20 °C

4: diethyl cyanophosphonate; triethylamine / N,N-dimethyl-formamide / 3.75 h / 0 - 20 °C

5: hydrogen bromide; acetic acid / 4 h / 0 - 20 °C

With hydrogenchloride; sodium hydroxide; diethyl cyanophosphonate; water; hydrogen bromide; acetic acid; triethylamine; In ethanol; hexane; water; N,N-dimethyl-formamide; 4: Schotten-Baumann Reaction;