6-(2-tritylsulfanyl-acetylamino)-hexanoic acid quinolin-3-ylamide

Base Information

• Chemical Name: 6-(2-tritylsulfanyl-acetylamino)-hexanoic acid quinolin-3-ylamide
• CAS No.: 852619-81-9
• Molecular Formula: C₃₆H₃₅N₃O₂S
• Molecular Weight: 573.759
• Mol file: 852619-81-9.mol

Synonyms:6-(2-tritylsulfanyl-acetylamino)-hexanoic acid quinolin-3-ylamide

Chemical Property of 6-(2-tritylsulfanyl-acetylamino)-hexanoic acid quinolin-3-ylamide

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 6-(2-tritylsulfanyl-acetylamino)-hexanoic acid quinolin-3-ylamide

There total 6 articles about 6-(2-tritylsulfanyl-acetylamino)-hexanoic acid quinolin-3-ylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-(tert-butoxycarbonylamino)hexanoic acid (6404-29-1) → 6-(2-tritylsulfanyl-acetylamino)-hexanoic acid quinolin-3-ylamide (852619-81-9)

Guidance literature:

Multi-step reaction with 3 steps

1: EDCI; HOBt; DIEA / CH₂Cl₂ / 12 h / 20 °C

2: HCl / diethyl ether / 4 h / 0 °C

3: EDCI; HOBt; DIEA / CH₂Cl₂ / 12 h / 20 °C

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In diethyl ether; dichloromethane;

DOI:10.1016/j.bmcl.2005.02.075

Reference yield:

6-amino-hexanoic acid quinolin-3-ylamide (852619-77-3) + 2-(triphenylmethylthio)ethanoic acid (34914-36-8) → 6-(2-tritylsulfanyl-acetylamino)-hexanoic acid quinolin-3-ylamide (852619-81-9)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 12h;

DOI:10.1016/j.bmcl.2005.02.075

Reference yield:

[5-(quinolin-3-ylcarbamoyl)-pentyl]-carbamic acid tert-butyl ester (852619-73-9) → 6-(2-tritylsulfanyl-acetylamino)-hexanoic acid quinolin-3-ylamide (852619-81-9)

Guidance literature:

Multi-step reaction with 2 steps

1: HCl / diethyl ether / 4 h / 0 °C

2: EDCI; HOBt; DIEA / CH₂Cl₂ / 12 h / 20 °C

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In diethyl ether; dichloromethane;

DOI:10.1016/j.bmcl.2005.02.075

upstream raw materials:

6-amino-hexanoic acid quinolin-3-ylamide

2-(triphenylmethylthio)ethanoic acid

[5-(quinolin-3-ylcarbamoyl)-pentyl]-carbamic acid tert-butyl ester

6-(tert-butoxycarbonylamino)hexanoic acid