(2R,3R,4S)-2-Allyl-4-(tert-butyldimethylsilyloxy)-3-methyl-1-triphenylmethyloxypentane

Base Information

Chemical Name:(2R,3R,4S)-2-Allyl-4-(tert-butyldimethylsilyloxy)-3-methyl-1-triphenylmethyloxypentane
CAS No.:210691-68-2
Molecular Formula:C₃₄H₄₆O₂Si
Molecular Weight:514.824
Hs Code.:

Synonyms:(2R,3R,4S)-2-Allyl-4-(tert-butyldimethylsilyloxy)-3-methyl-1-triphenylmethyloxypentane

Suppliers and Price of (2R,3R,4S)-2-Allyl-4-(tert-butyldimethylsilyloxy)-3-methyl-1-triphenylmethyloxypentane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2R,3R,4S)-2-Allyl-4-(tert-butyldimethylsilyloxy)-3-methyl-1-triphenylmethyloxypentane

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2R,3R,4S)-2-Allyl-4-(tert-butyldimethylsilyloxy)-3-methyl-1-triphenylmethyloxypentane

There total 9 articles about (2R,3R,4S)-2-Allyl-4-(tert-butyldimethylsilyloxy)-3-methyl-1-triphenylmethyloxypentane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 76-83-5
trityl chloride

: 210691-67-1
(2R,3R,4S)-2-Allyl-4-(tert-butyldimethylsilyloxy)-3-methylpentanol

: 210691-68-2
(2R,3R,4S)-2-Allyl-4-(tert-butyldimethylsilyloxy)-3-methyl-1-triphenylmethyloxypentane

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 20 ℃; for 12h;
DOI:10.1039/a909898d

Reference yield:

: 105198-40-1,105198-43-4,113034-39-2,151122-17-7,113034-38-1
ethyl (2E,4S)-4-<(tert-butyldimethylsilyl)oxy>-2-pentenoate

: 210691-68-2
(2R,3R,4S)-2-Allyl-4-(tert-butyldimethylsilyloxy)-3-methyl-1-triphenylmethyloxypentane

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / TMSCl, HMPA / tetrahydrofuran; diethyl ether / 1.) -95 deg C, 3.75 h, 2.) -50 deg C, 1 h

2: 99 percent / KHMDS / tetrahydrofuran / 3.5 h / -78 °C

3: 93 percent / DIBALH / CH₂Cl₂ / 1 h / 5 °C

4: 93 percent / Et₃N, DMAP / CH₂Cl₂ / 12 h / Ambient temperature

With N,N,N,N,N,N-hexamethylphosphoric triamide; dmap; chloro-trimethyl-silane; potassium hexamethylsilazane; diisobutylaluminium hydride; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1055/s-1998-1803

Reference yield:

: 105198-38-7,106513-42-2
ethyl (S)-2-(tert-butyldimethylsilyloxy)propanoate

: 210691-68-2
(2R,3R,4S)-2-Allyl-4-(tert-butyldimethylsilyloxy)-3-methyl-1-triphenylmethyloxypentane

Guidance literature:: Multi-step reaction with 6 steps

1: DIBALH / CH₂Cl₂

2: NaH / tetrahydrofuran

3: 95 percent / TMSCl, HMPA / tetrahydrofuran; diethyl ether / 1.) -95 deg C, 3.75 h, 2.) -50 deg C, 1 h

4: 99 percent / KHMDS / tetrahydrofuran / 3.5 h / -78 °C

5: 93 percent / DIBALH / CH₂Cl₂ / 1 h / 5 °C

6: 93 percent / Et₃N, DMAP / CH₂Cl₂ / 12 h / Ambient temperature

With N,N,N,N,N,N-hexamethylphosphoric triamide; dmap; chloro-trimethyl-silane; potassium hexamethylsilazane; sodium hydride; diisobutylaluminium hydride; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1055/s-1998-1803