(2R,3R,4S)-2-Allyl-4-(4-chlorobenzoyloxy)-3-methyl-1-triphenylmethyloxypentan-4-ol

Base Information

Chemical Name:(2R,3R,4S)-2-Allyl-4-(4-chlorobenzoyloxy)-3-methyl-1-triphenylmethyloxypentan-4-ol
CAS No.:210691-70-6
Molecular Formula:C₃₅H₃₅ClO₃
Molecular Weight:539.114
Hs Code.:

Synonyms:(2R,3R,4S)-2-Allyl-4-(4-chlorobenzoyloxy)-3-methyl-1-triphenylmethyloxypentan-4-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3R,4S)-2-Allyl-4-(4-chlorobenzoyloxy)-3-methyl-1-triphenylmethyloxypentan-4-ol

Chemical Property:

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Technology Process of (2R,3R,4S)-2-Allyl-4-(4-chlorobenzoyloxy)-3-methyl-1-triphenylmethyloxypentan-4-ol

There total 10 articles about (2R,3R,4S)-2-Allyl-4-(4-chlorobenzoyloxy)-3-methyl-1-triphenylmethyloxypentan-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 210691-69-3
(2R,3R,4S)-2-Allyl-3-methyl-1-triphenylmethyloxypentan-4-ol

: 74-11-3
para-chlorobenzoic acid

: 210691-70-6
(2R,3R,4S)-2-Allyl-4-(4-chlorobenzoyloxy)-3-methyl-1-triphenylmethyloxypentan-4-ol

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at -10 ℃; for 3h;
DOI:10.1055/s-1998-1803

Reference yield: 76.0%

: 210691-69-3
(2R,3R,4S)-2-Allyl-3-methyl-1-triphenylmethyloxypentan-4-ol

: 74-11-3
para-chlorobenzoic acid

: 210691-70-6
(2R,3R,4S)-2-Allyl-4-(4-chlorobenzoyloxy)-3-methyl-1-triphenylmethyloxypentan-4-ol

: C₂₈H₃₀O

: (2S,3R,4S)-2-Allyl-4-(4-chlorobenzoyloxy)-3-methyl-1-triphenylmethyloxypentan-4-ol

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at -10 - 0 ℃; for 3h;
DOI:10.1039/a909898d

Reference yield:

: 210691-67-1
(2R,3R,4S)-2-Allyl-4-(tert-butyldimethylsilyloxy)-3-methylpentanol

: 210691-70-6
(2R,3R,4S)-2-Allyl-4-(4-chlorobenzoyloxy)-3-methyl-1-triphenylmethyloxypentan-4-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / Et₃N; DMAP / CH₂Cl₂ / 12 h / 20 °C

2: 97 percent / TBAF*3H₂O / tetrahydrofuran / 5 h / Heating

3: 76 percent / DIAD; Ph₃P / tetrahydrofuran / 3 h / -10 - 0 °C

With dmap; di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; 1: Etherification / 2: Hydrolysis / 3: Esterification;
DOI:10.1039/a909898d