2-methylpropane-2-sulfinic acid [1-(2-methyl-1-ylphenyl)ethylidene]amide

Base Information

• Chemical Name: 2-methylpropane-2-sulfinic acid [1-(2-methyl-1-ylphenyl)ethylidene]amide
• CAS No.: 1208989-34-7
• Molecular Formula: C₁₂H₁₇NOS
• Molecular Weight: 223.339
• Mol file: 1208989-34-7.mol

Synonyms:2-methylpropane-2-sulfinic acid [1-(2-methyl-1-ylphenyl)ethylidene]amide

Chemical Property of 2-methylpropane-2-sulfinic acid [1-(2-methyl-1-ylphenyl)ethylidene]amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-methylpropane-2-sulfinic acid [1-(2-methyl-1-ylphenyl)ethylidene]amide

There total 1 articles about 2-methylpropane-2-sulfinic acid [1-(2-methyl-1-ylphenyl)ethylidene]amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

2-methylphenyl aldehyde (529-20-4) + (R)-2-methylpropane-2-sulfinamide (196929-78-9) → 2-methylpropane-2-sulfinic acid [1-(2-methyl-1-ylphenyl)ethylidene]amide (1208989-34-7)

Guidance literature:

With pyridinium p-toluenesulfonate; magnesium sulfate; In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1002/chem.201102655

Reference yield: 99.0%

2-methylpropane-2-sulfinic acid [1-(2-methyl-1-ylphenyl)ethylidene]amide (1208989-34-7) + C10H16BNO4 → (R(S))-N-((R,E)-1-(2-methylphenyl)hex-2-enyl)-2-methylpropane-2-sulfinamide (1133831-71-6)

Guidance literature:

With potassium phosphate; [Rh(OH)(cod)]2; o-phenylenebis(diphenylphosphine); In 1,4-dioxane; water; at 60 ℃; for 20h; optical yield given as %de; diastereoselective reaction; Inert atmosphere;

DOI:10.1021/jo100318s

Reference yield: 98.0%

4-chlorobut-1-yne (51908-64-6) + 2-methylpropane-2-sulfinic acid [1-(2-methyl-1-ylphenyl)ethylidene]amide (1208989-34-7) → (R)-N-((S)-5-chloro-1-(o-tolyl)pent-2-yn-1-yl)-2-methylpropane-2-sulfinamide

Guidance literature:

4-chlorobut-1-yne; With lithium hexamethyldisilazane; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h; Inert atmosphere;

2-methylpropane-2-sulfinic acid [1-(2-methyl-1-ylphenyl)ethylidene]amide; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 4.5h; diastereoselective reaction; Inert atmosphere;

DOI:10.1016/j.tetlet.2016.12.061

upstream raw materials:

2-methylphenyl aldehyde

(R)-2-methylpropane-2-sulfinamide

Downstream raw materials:

(R(S))-N-((R,E)-1-(2-methylphenyl)hex-2-enyl)-2-methylpropane-2-sulfinamide

(1S,2R)-1-((R)-1,1-dimethylethylsulfinamido)-1-o-tolylbut-3-en-2-yl benzoate

C₁₃H₁₈F₃NOS

C₁₃H₁₅NO