Technology Process of C13H6(2)H4
There total 4 articles about C13H6(2)H4 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl;
In
1,2-dimethoxyethane;
at 100 ℃;
for 3h;
Inert atmosphere;
DOI:10.1021/ol901854f
- Guidance literature:
-
With
potassium acetate; palladium diacetate; potassium hydrogencarbonate; isopropyl alcohol;
In
N,N-dimethyl acetamide; water; N,N-dimethyl-formamide;
at 75 ℃;
for 10h;
Time;
Overall yield = 68 %;
Schlenk technique;
Inert atmosphere;
DOI:10.1021/acs.orglett.6b01300
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / -78 °C / Inert atmosphere
1.2: 3 h / 20 °C
2.1: potassium carbonate; palladium diacetate / acetone; water / 65 °C / Sealed tube; Inert atmosphere
3.1: hydrogenchloride; sodium nitrite / water / 1 h / Cooling
3.2: 20 °C
4.1: palladium diacetate; potassium hydrogencarbonate; potassium acetate; isopropyl alcohol / water; N,N-dimethyl-formamide; N,N-dimethyl acetamide / 10 h / 75 °C / Schlenk technique; Inert atmosphere
With
hydrogenchloride; n-butyllithium; potassium acetate; palladium diacetate; potassium carbonate; potassium hydrogencarbonate; isopropyl alcohol; sodium nitrite;
In
tetrahydrofuran; hexane; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide; acetone;
DOI:10.1021/acs.orglett.6b01300
