(E)-(3-(4-cyanophenyl)-2-propenyl) methyl 2-tosylmalonate

Base Information

• Chemical Name: (E)-(3-(4-cyanophenyl)-2-propenyl) methyl 2-tosylmalonate
• CAS No.: 1096491-36-9
• Molecular Formula: C₂₁H₁₉NO₆S
• Molecular Weight: 413.451
• Mol file: 1096491-36-9.mol

Synonyms:(E)-(3-(4-cyanophenyl)-2-propenyl) methyl 2-tosylmalonate

Chemical Property of (E)-(3-(4-cyanophenyl)-2-propenyl) methyl 2-tosylmalonate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of (E)-(3-(4-cyanophenyl)-2-propenyl) methyl 2-tosylmalonate

There total 1 articles about (E)-(3-(4-cyanophenyl)-2-propenyl) methyl 2-tosylmalonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

(E)-3-(4-cyanophenyl)-2-propenyl methyl malonate (1096491-30-3) + p-toluenesulfonyl fluoride (455-16-3) → (3R*, 4S*)-methyl 4-(4-cyanobenzyl)-2-oxotetrahydrofuran-3-carboxylate + (E)-(3-(4-cyanophenyl)-2-propenyl) methyl 2-tosylmalonate (1096491-36-9)

Guidance literature:

(E)-3-(4-cyanophenyl)-2-propenyl methyl malonate; With potassium tert-butylate; In dimethyl sulfoxide; at 20 ℃; Inert atmosphere;

p-toluenesulfonyl fluoride; In dimethyl sulfoxide; at 20 ℃; for 23h; Inert atmosphere;

DOI:10.1039/b812306c

Reference yield: 80.0%

(E)-(3-(4-cyanophenyl)-2-propenyl) methyl 2-tosylmalonate (1096491-36-9) → methyl 3-(4-cyanophenyl)-2-tosylpent-4-enoate (1096491-42-7)

Guidance literature:

With t-butyldimethylsiyl triflate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 20 ℃; for 0.666667h; optical yield given as %de; Inert atmosphere;

DOI:10.1039/b812306c

upstream raw materials:

(E)-3-(4-cyanophenyl)-2-propenyl methyl malonate

p-toluenesulfonyl fluoride

Downstream raw materials:

methyl 3-(4-cyanophenyl)-2-tosylpent-4-enoate