12-benzyl-2-(cyclohexylcarbonyl)-1,2,3,4,6,7,12,12b-octahydropyrazino[2,1-a]β-carbolin-4-one

Base Information

Chemical Name:12-benzyl-2-(cyclohexylcarbonyl)-1,2,3,4,6,7,12,12b-octahydropyrazino[2,1-a]β-carbolin-4-one
CAS No.:1357104-25-6
Molecular Formula:C₂₈H₃₁N₃O₂
Molecular Weight:441.573
Hs Code.:

Synonyms:12-benzyl-2-(cyclohexylcarbonyl)-1,2,3,4,6,7,12,12b-octahydropyrazino[2,1-a]β-carbolin-4-one

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Chemical Property of 12-benzyl-2-(cyclohexylcarbonyl)-1,2,3,4,6,7,12,12b-octahydropyrazino[2,1-a]β-carbolin-4-one

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Technology Process of 12-benzyl-2-(cyclohexylcarbonyl)-1,2,3,4,6,7,12,12b-octahydropyrazino[2,1-a]β-carbolin-4-one

There total 7 articles about 12-benzyl-2-(cyclohexylcarbonyl)-1,2,3,4,6,7,12,12b-octahydropyrazino[2,1-a]β-carbolin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 100-39-0
benzyl bromide

: 106412-95-7
2-(cyclohexylcarbonyl)-1,2,3,4,6,7,12,12b-octahydropyrazino[2,1-a]β-carbolin-4-one

: 1357104-25-6
12-benzyl-2-(cyclohexylcarbonyl)-1,2,3,4,6,7,12,12b-octahydropyrazino[2,1-a]β-carbolin-4-one

Guidance literature:: With potassium hydroxide; In acetone; at 0 - 20 ℃; for 1h;
DOI:10.1016/j.bmcl.2011.11.108

Reference yield:

: 1357104-16-5
C₁₇H₁₉N₃O₂

: 1357104-25-6
12-benzyl-2-(cyclohexylcarbonyl)-1,2,3,4,6,7,12,12b-octahydropyrazino[2,1-a]β-carbolin-4-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen / methanol / 12 h

2.1: pyridine / 1 h / 0 - 20 °C

3.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

4.1: sodium hydroxide / dichloromethane / 0.5 h

4.2: 2 h / Reflux

5.1: potassium hydroxide / acetone / 1 h / 0 - 20 °C

With pyridine; hydrogen; trifluoroacetic acid; potassium hydroxide; sodium hydroxide; In methanol; dichloromethane; acetone;
DOI:10.1016/j.bmcl.2011.11.108

Reference yield:

: 1357104-18-7
C₂₄H₃₃N₃O₃

: 1357104-25-6
12-benzyl-2-(cyclohexylcarbonyl)-1,2,3,4,6,7,12,12b-octahydropyrazino[2,1-a]β-carbolin-4-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

2.1: sodium hydroxide / dichloromethane / 0.5 h

2.2: 2 h / Reflux

3.1: potassium hydroxide / acetone / 1 h / 0 - 20 °C

With trifluoroacetic acid; potassium hydroxide; sodium hydroxide; In dichloromethane; acetone;
DOI:10.1016/j.bmcl.2011.11.108