methyl 4-(4-hydroxy-3-(methoxycarbonyl)phenyl)-6-meth-yl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Base Information

• Chemical Name: methyl 4-(4-hydroxy-3-(methoxycarbonyl)phenyl)-6-meth-yl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
• CAS No.: 1448552-86-0
• Molecular Formula: C₁₅H₁₆N₂O₅S
• Molecular Weight: 336.368
• Mol file: 1448552-86-0.mol

Synonyms:methyl 4-(4-hydroxy-3-(methoxycarbonyl)phenyl)-6-meth-yl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Chemical Property of methyl 4-(4-hydroxy-3-(methoxycarbonyl)phenyl)-6-meth-yl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 4-(4-hydroxy-3-(methoxycarbonyl)phenyl)-6-meth-yl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

There total 1 articles about methyl 4-(4-hydroxy-3-(methoxycarbonyl)phenyl)-6-meth-yl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl-5-formyl-2-hydroxybenzoate (41489-76-3) + acetoacetic acid methyl ester (105-45-3) + thiourea (17356-08-0) → methyl 4-(4-hydroxy-3-(methoxycarbonyl)phenyl)-6-meth-yl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate (1448552-86-0)

Guidance literature:

With polyphosphoric acid; In ethanol; for 4h; Reflux;

DOI:10.1021/ci400196z

Reference yield:

1-bromo-4-phenylbutan-2-one (31984-10-8) + methyl 4-(4-hydroxy-3-(methoxycarbonyl)phenyl)-6-meth-yl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate (1448552-86-0) → C25H26N2O6S (1448553-05-6)

Guidance literature:

In tetrahydrofuran; water; at 20 ℃;

DOI:10.1021/ci400196z

Reference yield:

methyl 4-(4-hydroxy-3-(methoxycarbonyl)phenyl)-6-meth-yl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate (1448552-86-0) → C25H24N2O5S (1448553-06-7)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran; water / 20 °C

2: ethanol; water / Reflux

In tetrahydrofuran; ethanol; water;

DOI:10.1021/ci400196z

upstream raw materials:

methyl-5-formyl-2-hydroxybenzoate

acetoacetic acid methyl ester

thiourea

Downstream raw materials:

C₂₅H₂₄N₂O₅S

C₂₅H₂₆N₂O₆S