7-chloro-5-(2-fluorophenyl)-1,2-dihydro-2-<4-(iminomethyl)morpholinyl>-3H-1,4-benzodiazepine

Base Information

• Chemical Name: 7-chloro-5-(2-fluorophenyl)-1,2-dihydro-2-<4-(iminomethyl)morpholinyl>-3H-1,4-benzodiazepine
• CAS No.: 87120-60-3
• Molecular Formula: C₂₀H₂₀ClFN₄O
• Molecular Weight: 386.856

Synonyms:7-chloro-5-(2-fluorophenyl)-1,2-dihydro-2-<4-(iminomethyl)morpholinyl>-3H-1,4-benzodiazepine

Chemical Property of 7-chloro-5-(2-fluorophenyl)-1,2-dihydro-2-<4-(iminomethyl)morpholinyl>-3H-1,4-benzodiazepine

Chemical Property:

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Technology Process of 7-chloro-5-(2-fluorophenyl)-1,2-dihydro-2-<4-(iminomethyl)morpholinyl>-3H-1,4-benzodiazepine

There total 4 articles about 7-chloro-5-(2-fluorophenyl)-1,2-dihydro-2-<4-(iminomethyl)morpholinyl>-3H-1,4-benzodiazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

7-chloro-5-(2-fluorophenyl)-2,3-dihydro-N-hydroxy-alpha-(4-morpholinyl)-1H-1,4-benzodiazepine-2-methanimine (76488-28-3) → 7-chloro-5-(2-fluorophenyl)-1,2-dihydro-2-<4-(iminomethyl)morpholinyl>-3H-1,4-benzodiazepine (87120-60-3)

Guidance literature:

With ammonia; hydrogen; Ra-Ni; In tetrahydrofuran; ethanol; for 3h;

DOI:10.1002/jhet.5570200313

Reference yield:

7-chloro-5-(2-fluorophenyl)-N-hydroxy-alpha-nitro-3H-1,4-benzodiazepine-2-methanimine (76488-35-2) → 7-chloro-5-(2-fluorophenyl)-1,2-dihydro-2-<4-(iminomethyl)morpholinyl>-3H-1,4-benzodiazepine (87120-60-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 86 percent / tetrahydrofuran / 6 h / Ambient temperature

2: 74 percent / NaBH₄ / ethanol; tetrahydrofuran / 4 h / Ambient temperature

3: 74 percent / H₂, methanolic ammonia / Ra-Ni / ethanol; tetrahydrofuran / 3 h

With sodium tetrahydroborate; ammonia; hydrogen; Ra-Ni; In tetrahydrofuran; ethanol;

DOI:10.1002/jhet.5570200313

Reference yield:

7-chloro-5-(2-fluorophenyl)-2-<4-<(hydroxyimino)methyl>morpholinyl>-3H-1,4-benzodiazepine (76488-18-1) → 7-chloro-5-(2-fluorophenyl)-1,2-dihydro-2-<4-(iminomethyl)morpholinyl>-3H-1,4-benzodiazepine (87120-60-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 74 percent / NaBH₄ / ethanol; tetrahydrofuran / 4 h / Ambient temperature

2: 74 percent / H₂, methanolic ammonia / Ra-Ni / ethanol; tetrahydrofuran / 3 h

With sodium tetrahydroborate; ammonia; hydrogen; Ra-Ni; In tetrahydrofuran; ethanol;

DOI:10.1002/jhet.5570200313

upstream raw materials:

7-chloro-5-(2-fluorophenyl)-2,3-dihydro-N-hydroxy-alpha-(4-morpholinyl)-1H-1,4-benzodiazepine-2-methanimine

7-chloro-5-(2-fluorophenyl)-N-hydroxy-alpha-nitro-3H-1,4-benzodiazepine-2-methanimine

7-chloro-5-(2-fluorophenyl)-2-<4-<(hydroxyimino)methyl>morpholinyl>-3H-1,4-benzodiazepine

7-chloro-5-(2-fluorophenyl)-2-nitromethylene-1,3-dihydro-2H-1,4-benzodiazepine

Downstream raw materials:

8-chloro-6-(2-fluorophenyl)-3-(morpholinyl)-4H-imidazo<1,5-a><1,4>benzodiazepine

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