7-Chloro-1,3-dihydro-5-(2-fluorophenyl)-2-nitromethyl-ene-2H-1,4-benzodiazepine

Base Information

• Chemical Name: 7-Chloro-1,3-dihydro-5-(2-fluorophenyl)-2-nitromethyl-ene-2H-1,4-benzodiazepine
• CAS No.: 59467-63-9
• Molecular Formula: C16H11ClFN3O2
• Molecular Weight: 331.734
• Mol file: 59467-63-9.mol

Synonyms:7-Chloro-5-(2-fluorophenyl)-2,3-dihydro-2-(nitromethylene)-1H-1,4-benzodiazepi-ne;7-CHLOOR-5-(2-FLUORFENYL)-2-(NITROMETHYLEEN)-2,3-DIHYDRO-1H-1,4-BENZODIAZEPINE

Chemical Property of 7-Chloro-1,3-dihydro-5-(2-fluorophenyl)-2-nitromethyl-ene-2H-1,4-benzodiazepine

Chemical Property:

• PSA: 70.21000
• LogP: 3.95690

Purity/Quality:

99%+ ^*data from raw suppliers

7-Chloro-1,3-dihydro-5-(2-fluorophenyl)-2-nitromethyl-ene-2H-1,4-benzodiazepine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: An intermediate in the synthesis of midazolam (M343000).

Technology Process of 7-Chloro-1,3-dihydro-5-(2-fluorophenyl)-2-nitromethyl-ene-2H-1,4-benzodiazepine

There total 1 articles about 7-Chloro-1,3-dihydro-5-(2-fluorophenyl)-2-nitromethyl-ene-2H-1,4-benzodiazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 7-chloro-5-(2-fluorophenyl)-2-nitromethylene-1,3-dihydro-2H-1,4-benzodiazepine (59467-63-9)

Guidance literature:

aus 2-(Nitrosomethylamino-Verbindung) 2b mit Nitromethan;

DOI:10.1021/jo00399a029

Reference yield: 78.0%

7-chloro-5-(2-fluorophenyl)-2-nitromethylene-1,3-dihydro-2H-1,4-benzodiazepine (59467-63-9) → 7-chloro-5-(2-fluorophenyl)-N-hydroxy-alpha-nitro-3H-1,4-benzodiazepine-2-methanimine (76488-35-2)

Guidance literature:

With sodium nitrite; In acetic acid; for 0.25h; Ambient temperature;

DOI:10.1002/jhet.5570200313

Reference yield:

7-chloro-5-(2-fluorophenyl)-2-nitromethylene-1,3-dihydro-2H-1,4-benzodiazepine (59467-63-9) → Midazolam (59467-70-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 78 percent / NaNO₂ / acetic acid / 0.25 h / Ambient temperature

2: 53 percent / NaBH₄ / ethanol / 4 h / Ambient temperature

3: acetic acid / 0.17 h / Heating

With sodium tetrahydroborate; sodium nitrite; In ethanol; acetic acid;

DOI:10.1002/jhet.5570200313

Downstream raw materials:

7-chloro-5-(2-fluorophenyl)-N-hydroxy-alpha-nitro-3H-1,4-benzodiazepine-2-methanimine

7-chloro-5-(2-fluorophenyl)-3H-1,4-benzodiazepine-2-N'-hydroxycarboximidamide

7-chloro-5-(2-fluorophenyl)-3H-1,4-benzodiazepine-2-N'-hydroxy-N-methylcarboximidamide

7-chloro-5-(2-fluorophenyl)-N'-methoxy-3H-1,4-benzodiazepine-2-carboximidamide