ethyl (2E)-3-[5-(4-chlorophenyl)-4-iodo-1-phenyl-1H-pyrazol-3-yl]prop-2-enoate

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Chemical Name:ethyl (2E)-3-[5-(4-chlorophenyl)-4-iodo-1-phenyl-1H-pyrazol-3-yl]prop-2-enoate
CAS No.:1435483-50-3
Molecular Formula:C₂₀H₁₆ClIN₂O₂
Molecular Weight:478.717
Hs Code.:

Synonyms:ethyl (2E)-3-[5-(4-chlorophenyl)-4-iodo-1-phenyl-1H-pyrazol-3-yl]prop-2-enoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl (2E)-3-[5-(4-chlorophenyl)-4-iodo-1-phenyl-1H-pyrazol-3-yl]prop-2-enoate

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Technology Process of ethyl (2E)-3-[5-(4-chlorophenyl)-4-iodo-1-phenyl-1H-pyrazol-3-yl]prop-2-enoate

There total 1 articles about ethyl (2E)-3-[5-(4-chlorophenyl)-4-iodo-1-phenyl-1H-pyrazol-3-yl]prop-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 867-13-0
diethoxyphosphoryl-acetic acid ethyl ester

: 1002102-41-1
5-(4-chlorophenyl)-4-iodo-1-phenyl-3(1H)-pyrazolecarbaldehyde

: 1435483-50-3
ethyl (2E)-3-[5-(4-chlorophenyl)-4-iodo-1-phenyl-1H-pyrazol-3-yl]prop-2-enoate

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 6h;
DOI:10.1016/j.tet.2013.03.099

Reference yield: 74.0%

: 1435483-50-3
ethyl (2E)-3-[5-(4-chlorophenyl)-4-iodo-1-phenyl-1H-pyrazol-3-yl]prop-2-enoate

: 40138-16-7
2-formylbenzene boronic acid

: 1435483-39-8
ethyl (2E)-3-[5-(4-chlorophenyl)-4-(2-formylphenyl)-1-phenyl-1H-pyrazol-3-yl]prop-2-enoate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In N,N-dimethyl-formamide; at 90 ℃; for 3h; Inert atmosphere;
DOI:10.1016/j.tet.2013.03.099

Reference yield:

: 1435483-50-3
ethyl (2E)-3-[5-(4-chlorophenyl)-4-iodo-1-phenyl-1H-pyrazol-3-yl]prop-2-enoate

: ethyl rac-(1R,13S)-5-(4-chlorophenyl)-4-phenyl-3,4,14-triazapentacyclo[11.6.0.0^2,6.0^7,12.0^14,18]nonadeca-2,5,7,9,11-pentaene-19-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 3 h / 90 °C / Inert atmosphere

2: toluene / 110 °C / Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In N,N-dimethyl-formamide; toluene; 1: |Suzuki Coupling;
DOI:10.1016/j.tet.2013.03.099