Technology Process of (S)-3,3-dimethyl-2-phenylindoline
There total 8 articles about (S)-3,3-dimethyl-2-phenylindoline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
(R)-3,3'-bis(9-anthracenyl)-1,1'-binaphthyl-2,2'-diyl hydrogenphosphate; diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate;
In
toluene;
at 20 ℃;
for 16h;
optical yield given as %ee;
enantioselective reaction;
DOI:10.1021/ol1019234
- Guidance literature:
-
With
hydrogenchloride; (S)-3,3'-bis(2,4,6-tri-iso-propylphenyl)-1,1'-binaphthyl-2,2'-diyl hydrogenphosphate; bis(2,6-dichlorobenzyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; 4-acetylamino-2,2,6,6-tetramethylpiperidine-1-oxoammonium tetrafluoroborate;
In
diethyl ether; hexane; water;
for 24h;
Reagent/catalyst;
Solvent;
enantioselective reaction;
Autoclave;
Resolution of racemate;
DOI:10.1021/ja4082827
- Guidance literature:
-
Multi-step reaction with 2 steps
1: sodium tetrahydroborate / methanol / 5 h / 0 - 20 °C
2: 4-acetylamino-2,2,6,6-tetramethylpiperidine-1-oxoammonium tetrafluoroborate; hydrogenchloride; (S)-3,3'-bis-(2,4,4-tricyclohexylphenyl)-[1,1']-binaphthalenyl-2,2'-dioxaphosphoric acid; diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate / water; hexane; diethyl ether / 24 h / Autoclave; Resolution of racemate
With
hydrogenchloride; sodium tetrahydroborate; diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; (S)-3,3'-bis-(2,4,4-tricyclohexylphenyl)-[1,1']-binaphthalenyl-2,2'-dioxaphosphoric acid; 4-acetylamino-2,2,6,6-tetramethylpiperidine-1-oxoammonium tetrafluoroborate;
In
methanol; diethyl ether; hexane; water;
DOI:10.1021/ja4082827
