Propargyl-PEG5-t-butyl ester

Base Information

• Chemical Name: Propargyl-PEG5-t-butyl ester
• CAS No.: 1245823-50-0
• Molecular Formula: C₁₈H₃₂O₇
• Molecular Weight: 360.448
• Mol file: 1245823-50-0.mol

Synonyms:tert-butyl 4,7,10,13,16-pentaoxanonadec-18-ynoate

Chemical Property of Propargyl-PEG5-t-butyl ester

Chemical Property:

• Boiling Point: 420.6±40.0 °C(Predicted)
• Density: 1.045±0.06 g/cm3(Predicted)

Purity/Quality:

98%,99%, ^*data from raw suppliers

Propargyl-PEG5-t-butylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: Propargyl-PEG5-t-butyl ester has one of the functional groups protected by t-butyl group. The protection can be removed under acidic conditions. The propargyl group forms triazole linkages with azide-bearing compounds or biomolecules via copper catalyzed Click Chemistry. The PEG units help improving the water-solubility of the molecule in aqueous media.

Technology Process of Propargyl-PEG5-t-butyl ester

There total 2 articles about Propargyl-PEG5-t-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

tert-Butyl acrylate (1663-39-4,25232-27-3) + 3,6,9,12-tetraoxapentadec-14-yn-1-ol (87450-10-0) → tert-butyl 4,7,10,13,16-pentaoxanonadec-18-ynoate (1245823-50-0)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

DOI:10.1039/c0cc00784f

Reference yield:

tert-Butyl acrylate (1663-39-4,25232-27-3) + 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran (96042-30-7) → tert-butyl 4,7,10,13,16-pentaoxanonadec-18-ynoate (1245823-50-0)

Guidance literature:

With sodium; In tetrahydrofuran; methanol;

Reference yield: 100.0%

tert-butyl 4,7,10,13,16-pentaoxanonadec-18-ynoate (1245823-50-0) → 4,7,10,13,16‐pentaoxanonadec‐18‐ynoic acid (1245823-51-1,1421676-62-1)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1039/c0cc00784f

upstream raw materials:

tert-Butyl acrylate

3,6,9,12-tetraoxapentadec-14-yn-1-ol

4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran

Downstream raw materials:

4,7,10,13,16‐pentaoxanonadec‐18‐ynoic acid

Refernces

• 1、 Kumar, Amit,Erasquin, Uriel J.,Qin, Guoting,Li, King,Cai, Chengzhi. ""clickable", polymerized liposomes as a versatile and stable platform for rapid optimization of their peripheral compositions". . p. 5746 - 5748. Retrieved 2010.