(2S,3R)-N-tert-butyloxycarbonyl-3-benzylaspartic acid dibenzyl ester

Base Information

Chemical Name:(2S,3R)-N-tert-butyloxycarbonyl-3-benzylaspartic acid dibenzyl ester
CAS No.:349148-26-1
Molecular Formula:C₃₀H₃₃NO₆
Molecular Weight:503.595
Hs Code.:

Synonyms:(2S,3R)-N-tert-butyloxycarbonyl-3-benzylaspartic acid dibenzyl ester

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Chemical Property of (2S,3R)-N-tert-butyloxycarbonyl-3-benzylaspartic acid dibenzyl ester

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Technology Process of (2S,3R)-N-tert-butyloxycarbonyl-3-benzylaspartic acid dibenzyl ester

There total 1 articles about (2S,3R)-N-tert-butyloxycarbonyl-3-benzylaspartic acid dibenzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 100-39-0
benzyl bromide

: 80974-42-1
(S)-N-tert-butyloxycarbonylaspartic acid dibenzyl ester

: 349148-26-1
(2S,3R)-N-tert-butyloxycarbonyl-3-benzylaspartic acid dibenzyl ester

Guidance literature:: (S)-N-tert-butyloxycarbonylaspartic acid dibenzyl ester; With lithium hexamethyldisilazane; In tetrahydrofuran; hexane; at -78 ℃; for 2h;

benzyl bromide; In tetrahydrofuran; hexane; for 12h; Further stages.;
DOI:10.1021/jo0014055

Reference yield: 80.0%

: 101-83-7
N-cyclohexyl-cyclohexanamine

: 349148-26-1
(2S,3R)-N-tert-butyloxycarbonyl-3-benzylaspartic acid dibenzyl ester

: (2R,3S)-2-Benzyl-3-tert-butoxycarbonylamino-succinic acid 1-benzyl ester; compound with dicyclohexyl-amine

Guidance literature:: (2S,3R)-N-tert-butyloxycarbonyl-3-benzylaspartic acid dibenzyl ester; With sodium hydroxide; In 1,4-dioxane; at 20 ℃; for 24h;

N-cyclohexyl-cyclohexanamine; In diethyl ether; for 24h; Further stages.; refrigerator;
DOI:10.1021/jo010421e

Reference yield:

: 349148-26-1
(2S,3R)-N-tert-butyloxycarbonyl-3-benzylaspartic acid dibenzyl ester

: C₂₄H₂₆ClNO₇

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / NaOH / dioxane; H₂O / 24 h / 20 °C

2: Et₃N / 1,2-dimethoxy-ethane / 0.5 h

With sodium hydroxide; triethylamine; In 1,4-dioxane; 1,2-dimethoxyethane; water;
DOI:10.1021/jo0014055