(4R,6R)-4-(dimethylphenylsilyl)-6-[(R)-2-hydroxypent-4-en-1-yl]-3,4,5,6-tetrahydro-2H-pyran-2-one

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Chemical Name:(4R,6R)-4-(dimethylphenylsilyl)-6-[(R)-2-hydroxypent-4-en-1-yl]-3,4,5,6-tetrahydro-2H-pyran-2-one
CAS No.:1643685-76-0
Molecular Formula:C₁₈H₂₆O₃Si
Molecular Weight:318.488
Hs Code.:

Synonyms:(4R,6R)-4-(dimethylphenylsilyl)-6-[(R)-2-hydroxypent-4-en-1-yl]-3,4,5,6-tetrahydro-2H-pyran-2-one

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Chemical Property of (4R,6R)-4-(dimethylphenylsilyl)-6-[(R)-2-hydroxypent-4-en-1-yl]-3,4,5,6-tetrahydro-2H-pyran-2-one

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Technology Process of (4R,6R)-4-(dimethylphenylsilyl)-6-[(R)-2-hydroxypent-4-en-1-yl]-3,4,5,6-tetrahydro-2H-pyran-2-one

There total 8 articles about (4R,6R)-4-(dimethylphenylsilyl)-6-[(R)-2-hydroxypent-4-en-1-yl]-3,4,5,6-tetrahydro-2H-pyran-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 1643685-75-9
(4R,6R)-4-(dimethylphenylsilyl)-6-{[(6S)-4-(dimethylphenylsilyl)-2,2-dioxo-1,2-oxathian-6-yl]methyl}-3,4,5,6-tetrahydro-2H-pyran-2-one

: 1643685-76-0
(4R,6R)-4-(dimethylphenylsilyl)-6-[(R)-2-hydroxypent-4-en-1-yl]-3,4,5,6-tetrahydro-2H-pyran-2-one

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 ℃; for 1.5h; Inert atmosphere;
DOI:10.1002/ejoc.201400145

Reference yield:

: 1643685-69-1
(4S,6R)-6-[(ethenesulfonyl)oxy]nona-1,8-dien-4-yl (E)-but-2-enoate

: 1643685-76-0
(4R,6R)-4-(dimethylphenylsilyl)-6-[(R)-2-hydroxypent-4-en-1-yl]-3,4,5,6-tetrahydro-2H-pyran-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: Schwartz's reagent / toluene / 3 h / 100 °C / Inert atmosphere

2.1: lithium / tetrahydrofuran / 18 h / -10 °C / Inert atmosphere

2.2: 3 h / -78 - -50 °C / Inert atmosphere

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h / 0 °C / Inert atmosphere

With Schwartz's reagent; tetrabutyl ammonium fluoride; lithium; In tetrahydrofuran; toluene;
DOI:10.1002/ejoc.201400145

Reference yield:

: (4R,6R)-nona-1,8-diene-4,6-diol

: 1643685-76-0
(4R,6R)-4-(dimethylphenylsilyl)-6-[(R)-2-hydroxypent-4-en-1-yl]-3,4,5,6-tetrahydro-2H-pyran-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: triphenylphosphine; di-isopropyl azodicarboxylate / toluene / -30 - 20 °C / Inert atmosphere

2.1: triethylamine / tetrahydrofuran / 0.5 h / 15 °C / Inert atmosphere

3.1: Schwartz's reagent / toluene / 3 h / 100 °C / Inert atmosphere

4.1: lithium / tetrahydrofuran / 18 h / -10 °C / Inert atmosphere

4.2: 3 h / -78 - -50 °C / Inert atmosphere

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h / 0 °C / Inert atmosphere

With Schwartz's reagent; di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; lithium; triethylamine; triphenylphosphine; In tetrahydrofuran; toluene; 1.1: |Mitsunobu Displacement;
DOI:10.1002/ejoc.201400145