10-(2-{[tert-butyl(diphenyl)silyl]oxy}-4-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]butyl)-N,N-diethyl-10H-phenothiazin-2-amine

Base Information

Chemical Name:10-(2-{[tert-butyl(diphenyl)silyl]oxy}-4-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]butyl)-N,N-diethyl-10H-phenothiazin-2-amine
CAS No.:1442371-88-1
Molecular Formula:C₄₄H₅₀N₆O₂SSi
Molecular Weight:755.072
Hs Code.:

Synonyms:10-(2-{[tert-butyl(diphenyl)silyl]oxy}-4-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]butyl)-N,N-diethyl-10H-phenothiazin-2-amine

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Chemical Property of 10-(2-{[tert-butyl(diphenyl)silyl]oxy}-4-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]butyl)-N,N-diethyl-10H-phenothiazin-2-amine

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Technology Process of 10-(2-{[tert-butyl(diphenyl)silyl]oxy}-4-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]butyl)-N,N-diethyl-10H-phenothiazin-2-amine

There total 2 articles about 10-(2-{[tert-butyl(diphenyl)silyl]oxy}-4-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]butyl)-N,N-diethyl-10H-phenothiazin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1442371-84-7
10-(2-{[tert-butyl(diphenyl)silyl]oxy}-4-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]butyl)-2-chloro-10H-phenothiazine

: 109-73-9,85404-21-3
N-butylamine

: 1442371-88-1
10-(2-{[tert-butyl(diphenyl)silyl]oxy}-4-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]butyl)-N,N-diethyl-10H-phenothiazin-2-amine

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium t-butanolate; XPhos; In toluene; at 100 - 110 ℃; for 4h; Inert atmosphere;
DOI:10.1016/j.bmc.2013.04.034

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 1442371-88-1
10-(2-{[tert-butyl(diphenyl)silyl]oxy}-4-[2-(4-methoxyphenyl)-2H-tetrazol-5-yl]butyl)-N,N-diethyl-10H-phenothiazin-2-amine

Guidance literature:: Multi-step reaction with 2 steps

1: 1H-imidazole / dichloromethane / 96 h / 0 - 20 °C / Inert atmosphere

2: XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium t-butanolate / toluene / 4 h / 100 - 110 °C / Inert atmosphere

With 1H-imidazole; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium t-butanolate; XPhos; In dichloromethane; toluene; 2: |Buchwald-Hartwig Coupling;
DOI:10.1016/j.bmc.2013.04.034