(1R,3R)-methyl 3-[(S)-1-(benzyloxycarbonylamino)-4-tertbutoxy-4-oxobutan-2-yl]-2,2-dimethylcyclobutanecarboxylate

Base Information

Chemical Name:(1R,3R)-methyl 3-[(S)-1-(benzyloxycarbonylamino)-4-tertbutoxy-4-oxobutan-2-yl]-2,2-dimethylcyclobutanecarboxylate
CAS No.:1138793-54-0
Molecular Formula:C₂₄H₃₅NO₆
Molecular Weight:433.545
Hs Code.:

Synonyms:(1R,3R)-methyl 3-[(S)-1-(benzyloxycarbonylamino)-4-tertbutoxy-4-oxobutan-2-yl]-2,2-dimethylcyclobutanecarboxylate

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Chemical Property of (1R,3R)-methyl 3-[(S)-1-(benzyloxycarbonylamino)-4-tertbutoxy-4-oxobutan-2-yl]-2,2-dimethylcyclobutanecarboxylate

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Technology Process of (1R,3R)-methyl 3-[(S)-1-(benzyloxycarbonylamino)-4-tertbutoxy-4-oxobutan-2-yl]-2,2-dimethylcyclobutanecarboxylate

There total 1 articles about (1R,3R)-methyl 3-[(S)-1-(benzyloxycarbonylamino)-4-tertbutoxy-4-oxobutan-2-yl]-2,2-dimethylcyclobutanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1138793-52-8
benzyl (2S,1'R,3'R)-3-(tert-butoxycarbonyl)-2-(2',2'-dimethyl-3'-carboxycyclobutyl)propylcarbamate

: 74-88-4
methyl iodide

: 1138793-54-0
(1R,3R)-methyl 3-[(S)-1-(benzyloxycarbonylamino)-4-tertbutoxy-4-oxobutan-2-yl]-2,2-dimethylcyclobutanecarboxylate

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 16h;
DOI:10.1016/j.tetasy.2008.12.019

Reference yield:

: 1138793-54-0
(1R,3R)-methyl 3-[(S)-1-(benzyloxycarbonylamino)-4-tertbutoxy-4-oxobutan-2-yl]-2,2-dimethylcyclobutanecarboxylate

: C₂₁H₂₉NO₆

Guidance literature:: Multi-step reaction with 2 steps

1: silver(l) oxide / N,N-dimethyl-formamide / 168 h / 20 °C / Darkness

2: trifluoroacetic acid; triethylsilane / dichloromethane / 18 h / 20 °C

With triethylsilane; trifluoroacetic acid; silver(l) oxide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2015.08.044

Reference yield:

: 1138793-54-0
(1R,3R)-methyl 3-[(S)-1-(benzyloxycarbonylamino)-4-tertbutoxy-4-oxobutan-2-yl]-2,2-dimethylcyclobutanecarboxylate

: C₄₂H₅₆N₂O₁₁

Guidance literature:: Multi-step reaction with 3 steps

1: silver(l) oxide / N,N-dimethyl-formamide / 168 h / 20 °C / Darkness

2: trifluoroacetic acid; triethylsilane / dichloromethane / 18 h / 20 °C

3: triethylamine; chloroformic acid ethyl ester / acetone / 0.5 h / 0 °C / Cooling with ice

With triethylsilane; chloroformic acid ethyl ester; triethylamine; trifluoroacetic acid; silver(l) oxide; In dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1016/j.tet.2015.08.044