(1R,2R,3R,4S)-4-nitrobenzoic acid 4-[4-(4-benzyloxy-3-methoxyphenyl)-1-hydroxy-4-methoxymethoxy-2,3-dimethylbutyl]-2-methoxyphenyl ester

Base Information

Chemical Name:(1R,2R,3R,4S)-4-nitrobenzoic acid 4-[4-(4-benzyloxy-3-methoxyphenyl)-1-hydroxy-4-methoxymethoxy-2,3-dimethylbutyl]-2-methoxyphenyl ester
CAS No.:915158-65-5
Molecular Formula:C₃₆H₃₉NO₁₀
Molecular Weight:645.706
Hs Code.:

Synonyms:(1R,2R,3R,4S)-4-nitrobenzoic acid 4-[4-(4-benzyloxy-3-methoxyphenyl)-1-hydroxy-4-methoxymethoxy-2,3-dimethylbutyl]-2-methoxyphenyl ester

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Chemical Property of (1R,2R,3R,4S)-4-nitrobenzoic acid 4-[4-(4-benzyloxy-3-methoxyphenyl)-1-hydroxy-4-methoxymethoxy-2,3-dimethylbutyl]-2-methoxyphenyl ester

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Technology Process of (1R,2R,3R,4S)-4-nitrobenzoic acid 4-[4-(4-benzyloxy-3-methoxyphenyl)-1-hydroxy-4-methoxymethoxy-2,3-dimethylbutyl]-2-methoxyphenyl ester

There total 6 articles about (1R,2R,3R,4S)-4-nitrobenzoic acid 4-[4-(4-benzyloxy-3-methoxyphenyl)-1-hydroxy-4-methoxymethoxy-2,3-dimethylbutyl]-2-methoxyphenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 915158-64-4
(1R,2R,3R,4S)-4-[4-(4-benzyloxy-3-methoxyphenyl)-1-hydroxy-4-methoxymethoxy-2,3-dimethylbutyl]-2-methoxyphenol

: 122-04-3
4-nitro-benzoyl chloride

: 915158-65-5
(1R,2R,3R,4S)-4-nitrobenzoic acid 4-[4-(4-benzyloxy-3-methoxyphenyl)-1-hydroxy-4-methoxymethoxy-2,3-dimethylbutyl]-2-methoxyphenyl ester

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 0.25h;
DOI:10.1021/ol0621710

Reference yield:

: (1R,2R,3R)-1-(4-allyloxy-3-methoxyphenyl)-4-(4-benzyloxy-3-methoxyphenyl)-4-methoxymethoxy-2,3-dimethylbutan-1-ol

: 915158-65-5
(1R,2R,3R,4S)-4-nitrobenzoic acid 4-[4-(4-benzyloxy-3-methoxyphenyl)-1-hydroxy-4-methoxymethoxy-2,3-dimethylbutyl]-2-methoxyphenyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: Pd(PPh₃)4; NaBH₄ / tetrahydrofuran

2: 94 percent / Et₃N / CH₂Cl₂

With sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1055/s-2007-968019

Reference yield:

: 915158-62-2
(2R,3R,4R)-4-(4-allyloxy-3-methoxyphenyl)-4-(tert-butyldimethylsilanyloxy)-2,3-dimethylbutyraldehyde

: 915158-65-5
(1R,2R,3R,4S)-4-nitrobenzoic acid 4-[4-(4-benzyloxy-3-methoxyphenyl)-1-hydroxy-4-methoxymethoxy-2,3-dimethylbutyl]-2-methoxyphenyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 76 percent / CeCl₃ / tetrahydrofuran

2: Huenig's base

3: TBAF / tetrahydrofuran

4: Pd(PPh₃)4; NaBH₄ / tetrahydrofuran

5: 94 percent / Et₃N / CH₂Cl₂

With sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; cerium(III) chloride; tetrabutyl ammonium fluoride; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1055/s-2007-968019