N-pentanoyl-N-{[2'-(2N-trityl-tetrazole-5-yl)(1,1'-biphenyl)-4-yl]methyl}-L-valine methyl ester

Base Information

Chemical Name:N-pentanoyl-N-{[2'-(2N-trityl-tetrazole-5-yl)(1,1'-biphenyl)-4-yl]methyl}-L-valine methyl ester
CAS No.:883223-10-7
Molecular Formula:C₄₄H₄₅N₅O₃
Molecular Weight:691.873
Hs Code.:

Synonyms:N-pentanoyl-N-{[2'-(2N-trityl-tetrazole-5-yl)(1,1'-biphenyl)-4-yl]methyl}-L-valine methyl ester

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Chemical Property of N-pentanoyl-N-{[2'-(2N-trityl-tetrazole-5-yl)(1,1'-biphenyl)-4-yl]methyl}-L-valine methyl ester

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Technology Process of N-pentanoyl-N-{[2'-(2N-trityl-tetrazole-5-yl)(1,1'-biphenyl)-4-yl]methyl}-L-valine methyl ester

There total 7 articles about N-pentanoyl-N-{[2'-(2N-trityl-tetrazole-5-yl)(1,1'-biphenyl)-4-yl]methyl}-L-valine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 852160-37-3
N-[[2'-(2N-trityl-tetrazole-5-yl)[1,1'-biphenyl]-4-yl]methyl]-L-valine methyl-ester hydrobromide

: 638-29-9
n-valeryl chloride

: 883223-10-7
N-pentanoyl-N-{[2'-(2N-trityl-tetrazole-5-yl)(1,1'-biphenyl)-4-yl]methyl}-L-valine methyl ester

Guidance literature:: N-[[2'-(2N-trityl-tetrazole-5-yl)[1,1'-biphenyl]-4-yl]methyl]-L-valine methyl-ester hydrobromide; With triethylamine; In dichloromethane; at -5 ℃; for 0.333333h;

n-valeryl chloride; In dichloromethane; at 0 - 20 ℃; for 50h; Product distribution / selectivity;

Reference yield:

: 883223-08-3
(S)-methyl 3-methyl-2-((4-(4,4,5,5-tetramethyl-2,3,2-dioxaborolan-2-yl)benzyl)amino)butanoate

: 883223-10-7
N-pentanoyl-N-{[2'-(2N-trityl-tetrazole-5-yl)(1,1'-biphenyl)-4-yl]methyl}-L-valine methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / pyridine / CH₂Cl₂ / 0 °C

2: 80 percent / aq. Na₂CO₃ / Pd(PPh₃)4 / toluene / 10 h / 80 °C

With pyridine; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; toluene; 2: Suzuki coupling;
DOI:10.1055/s-2006-926234

Reference yield:

: 2042-37-7
o-cyanobromobenzene

: 883223-10-7
N-pentanoyl-N-{[2'-(2N-trityl-tetrazole-5-yl)(1,1'-biphenyl)-4-yl]methyl}-L-valine methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / NH₄Cl; NaN₃; LiCl / dimethylformamide / 10 h / 100 °C

2: 90 percent / Et₃N / CH₂Cl₂ / 3 h / 20 °C

3: 80 percent / aq. Na₂CO₃ / Pd(PPh₃)4 / toluene / 10 h / 80 °C

With sodium azide; sodium carbonate; ammonium chloride; triethylamine; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; N,N-dimethyl-formamide; toluene; 3: Suzuki coupling;
DOI:10.1055/s-2006-926234