2,4-Diacetoxybenzamide

Base Information

• Chemical Name: 2,4-Diacetoxybenzamide
• CAS No.: 195723-39-8
• Molecular Formula: C₁₁H₁₁NO₅
• Molecular Weight: 237.212
• DSSTox Substance ID: DTXSID701310625
• Nikkaji Number: J906.014F
• Mol file: 195723-39-8.mol

Synonyms:2,4-Diacetoxybenzamide;2,4-Bis(acetyloxy)benzamide;DTXSID701310625;195723-39-8

Chemical Property of 2,4-Diacetoxybenzamide

Chemical Property:

• XLogP3: 0.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 5
• Exact Mass: 237.06372245
• Heavy Atom Count: 17
• Complexity: 328

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(=O)OC1=CC(=C(C=C1)C(=O)N)OC(=O)C

Technology Process of 2,4-Diacetoxybenzamide

There total 3 articles about 2,4-Diacetoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,4-diacetoxybenzoyl chloride (50740-12-0) → 2,4-diacetoxybenzamide (195723-39-8)

Guidance literature:

2,4-diacetoxybenzoyl chloride; With ammonium hydroxide; at 5 - 25 ℃; for 2h;

With dmap; acetic anhydride;

Reference yield:

4-hydroxysalicylic acid (89-86-1) → 2,4-diacetoxybenzamide (195723-39-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: H₂SO₄

2.1: SOCl₂ / 3 h / Heating

3.1: aq. NH₃ / 2 h / 5 - 25 °C

3.2: Ac₂O; N,N-dimethylaminopyridine

With ammonium hydroxide; thionyl chloride; sulfuric acid;

Reference yield:

2,4-bis(acetyloxy)benzoic acid (51-01-4) → 2,4-diacetoxybenzamide (195723-39-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: SOCl₂ / 3 h / Heating

2.1: aq. NH₃ / 2 h / 5 - 25 °C

2.2: Ac₂O; N,N-dimethylaminopyridine

With ammonium hydroxide; thionyl chloride;

upstream raw materials:

2,4-diacetoxybenzoyl chloride

4-hydroxysalicylic acid

2,4-bis(acetyloxy)benzoic acid

Downstream raw materials:

2,4-dihydroxybenzamide

Refernces