tert-butyl (2S,3R)-3-(tert-butyldimethylsilyloxy)-6-hydroxy-1-(4-(methoxymethoxy)phenyl)hexan-2-yl(methyl)carbamate

Base Information

Chemical Name:tert-butyl (2S,3R)-3-(tert-butyldimethylsilyloxy)-6-hydroxy-1-(4-(methoxymethoxy)phenyl)hexan-2-yl(methyl)carbamate
CAS No.:1093169-40-4
Molecular Formula:C₂₆H₄₇NO₆Si
Molecular Weight:497.748
Hs Code.:

Synonyms:tert-butyl (2S,3R)-3-(tert-butyldimethylsilyloxy)-6-hydroxy-1-(4-(methoxymethoxy)phenyl)hexan-2-yl(methyl)carbamate

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Chemical Property of tert-butyl (2S,3R)-3-(tert-butyldimethylsilyloxy)-6-hydroxy-1-(4-(methoxymethoxy)phenyl)hexan-2-yl(methyl)carbamate

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Technology Process of tert-butyl (2S,3R)-3-(tert-butyldimethylsilyloxy)-6-hydroxy-1-(4-(methoxymethoxy)phenyl)hexan-2-yl(methyl)carbamate

There total 8 articles about tert-butyl (2S,3R)-3-(tert-butyldimethylsilyloxy)-6-hydroxy-1-(4-(methoxymethoxy)phenyl)hexan-2-yl(methyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1093169-25-5
tert-butyl (1S,2R)-[2,5-bis(tert-butyldimethylsilyloxy)-1-[4-(methoxymethoxy)benzyl]pentyl]methylcarbamate

: 1093169-40-4
tert-butyl (2S,3R)-3-(tert-butyldimethylsilyloxy)-6-hydroxy-1-(4-(methoxymethoxy)phenyl)hexan-2-yl(methyl)carbamate

Guidance literature:: With Dowex-50; In methanol; water; at 20 ℃;
DOI:10.1016/j.tetlet.2008.09.141

Reference yield:

: C₃₂H₆₁NO₆Si₂

: 1093169-40-4
tert-butyl (2S,3R)-3-(tert-butyldimethylsilyloxy)-6-hydroxy-1-(4-(methoxymethoxy)phenyl)hexan-2-yl(methyl)carbamate

: 1159215-98-1
tert-butyl (1R,2S)-[2-(tert-butyldimethylsilyloxy)-5-hydroxy-1-[4-(methoxymethoxy)benzyl]pentyl]methylcarbamate

Guidance literature:: With Dowex-50; In methanol; water; at 20 ℃; optical yield given as %ee;
DOI:10.1016/j.tetlet.2008.09.141

Reference yield:

: 1353674-49-3
(2S,3R)-3-(tert-butyldimethylsilyloxy)-1-(4-(methoxymethoxy)phenyl)-N-methyl-N-((S)-1-phenylethyl)-6-(triisopropylsilyloxy)hexan-2-amine

: 1093169-40-4
tert-butyl (2S,3R)-3-(tert-butyldimethylsilyloxy)-6-hydroxy-1-(4-(methoxymethoxy)phenyl)hexan-2-yl(methyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine; triethylamine hydrofluoride / 26 h / Inert atmosphere

2: hydrogen; palladium(II) hydroxide / ethanol / 3 h

3: ethanol / 1 h / Inert atmosphere

With pyridine; hydrogen; palladium(II) hydroxide; triethylamine hydrofluoride; In ethanol;
DOI:10.1021/ol202683k