(2S,3R)-3-(tert-butyldimethylsilyloxy)-1-(4-(methoxymethoxy)phenyl)-N-methyl-N-((S)-1-phenylethyl)-6-(triisopropylsilyloxy)hexan-2-amine

Base Information

Chemical Name:(2S,3R)-3-(tert-butyldimethylsilyloxy)-1-(4-(methoxymethoxy)phenyl)-N-methyl-N-((S)-1-phenylethyl)-6-(triisopropylsilyloxy)hexan-2-amine
CAS No.:1353674-49-3
Molecular Formula:C₃₈H₆₇NO₄Si₂
Molecular Weight:658.125
Hs Code.:

Synonyms:(2S,3R)-3-(tert-butyldimethylsilyloxy)-1-(4-(methoxymethoxy)phenyl)-N-methyl-N-((S)-1-phenylethyl)-6-(triisopropylsilyloxy)hexan-2-amine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,3R)-3-(tert-butyldimethylsilyloxy)-1-(4-(methoxymethoxy)phenyl)-N-methyl-N-((S)-1-phenylethyl)-6-(triisopropylsilyloxy)hexan-2-amine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (2S,3R)-3-(tert-butyldimethylsilyloxy)-1-(4-(methoxymethoxy)phenyl)-N-methyl-N-((S)-1-phenylethyl)-6-(triisopropylsilyloxy)hexan-2-amine

There total 7 articles about (2S,3R)-3-(tert-butyldimethylsilyloxy)-1-(4-(methoxymethoxy)phenyl)-N-methyl-N-((S)-1-phenylethyl)-6-(triisopropylsilyloxy)hexan-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: CF₃O₃S^(1-)*C₃₀H₅₈NO₂Si₂⁽¹⁺⁾

: (4-(methoxymethoxy)phenyl)magnesium bromide

: 1353674-49-3
(2S,3R)-3-(tert-butyldimethylsilyloxy)-1-(4-(methoxymethoxy)phenyl)-N-methyl-N-((S)-1-phenylethyl)-6-(triisopropylsilyloxy)hexan-2-amine

Guidance literature:: With copper(l) iodide; In tetrahydrofuran; 1,4-dioxane; at 0 ℃; for 0.166667h; Inert atmosphere;
DOI:10.1021/ol202683k

Reference yield:

: 618884-71-2
(S)-N-methoxy-N-methyl-1-((S)-1-phenylethyl)aziridine-2-carboxamide

: 1353674-49-3
(2S,3R)-3-(tert-butyldimethylsilyloxy)-1-(4-(methoxymethoxy)phenyl)-N-methyl-N-((S)-1-phenylethyl)-6-(triisopropylsilyloxy)hexan-2-amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: tert.-butyl lithium / diethyl ether; pentane / 0.5 h / -78 °C / Inert atmosphere

1.2: 2.5 h / -78 - 20 °C / Inert atmosphere

2.1: sodium tetrahydroborate; zinc(II) chloride / methanol / 0.5 h / -78 °C / Inert atmosphere

2.2: Inert atmosphere

3.1: dmap / dichloromethane / 12 h / 0 °C / Inert atmosphere

4.1: 1,4-dioxane / 0.08 h / 20 °C / Inert atmosphere

5.1: copper(l) iodide / tetrahydrofuran; 1,4-dioxane / 0.17 h / 0 °C / Inert atmosphere

With dmap; sodium tetrahydroborate; copper(l) iodide; tert.-butyl lithium; zinc(II) chloride; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; dichloromethane; pentane;
DOI:10.1021/ol202683k

Reference yield:

: 1353674-47-1
C₂₃H₃₉NO₂Si

: 1353674-49-3
(2S,3R)-3-(tert-butyldimethylsilyloxy)-1-(4-(methoxymethoxy)phenyl)-N-methyl-N-((S)-1-phenylethyl)-6-(triisopropylsilyloxy)hexan-2-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium tetrahydroborate; zinc(II) chloride / methanol / 0.5 h / -78 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: dmap / dichloromethane / 12 h / 0 °C / Inert atmosphere

3.1: 1,4-dioxane / 0.08 h / 20 °C / Inert atmosphere

4.1: copper(l) iodide / tetrahydrofuran; 1,4-dioxane / 0.17 h / 0 °C / Inert atmosphere

With dmap; sodium tetrahydroborate; copper(l) iodide; zinc(II) chloride; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane;
DOI:10.1021/ol202683k