(E)-N’-((1-(2-hydroxyethyl)-1H-indol-4-yl)methylene)-2-(mesityloxy)acetohydrazide

Base Information

• Chemical Name: (E)-N’-((1-(2-hydroxyethyl)-1H-indol-4-yl)methylene)-2-(mesityloxy)acetohydrazide
• CAS No.: 1572183-90-4
• Molecular Formula: C₂₂H₂₅N₃O₃
• Molecular Weight: 379.459
• Mol file: 1572183-90-4.mol

Synonyms:(E)-N’-((1-(2-hydroxyethyl)-1H-indol-4-yl)methylene)-2-(mesityloxy)acetohydrazide

Chemical Property of (E)-N’-((1-(2-hydroxyethyl)-1H-indol-4-yl)methylene)-2-(mesityloxy)acetohydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-N’-((1-(2-hydroxyethyl)-1H-indol-4-yl)methylene)-2-(mesityloxy)acetohydrazide

There total 4 articles about (E)-N’-((1-(2-hydroxyethyl)-1H-indol-4-yl)methylene)-2-(mesityloxy)acetohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 3.3%

2-(mesitylamino)acetohydrazide (750624-66-9) + 1-(2-hydroxyethyl)-1H-indol-4-carbaldehyde (1341619-34-8) → (E)-N’-((1-(2-hydroxyethyl)-1H-indol-4-yl)methylene)-2-(mesityloxy)acetohydrazide (1572183-90-4)

Guidance literature:

In acetic acid; dimethyl sulfoxide; at 20 ℃; for 12h;

Reference yield:

2,4,6-trimethylbenzamide (4380-68-1) → (E)-N’-((1-(2-hydroxyethyl)-1H-indol-4-yl)methylene)-2-(mesityloxy)acetohydrazide (1572183-90-4)

Guidance literature:

Multi-step reaction with 3 steps

1: caesium carbonate / acetonitrile / 16 h / Reflux

2: ethanol / 16 h / 100 °C

3: dimethyl sulfoxide; acetic acid / 12 h / 20 °C

With caesium carbonate; In ethanol; acetic acid; dimethyl sulfoxide; acetonitrile;

Reference yield:

methyl 2-(mesitylamino)acetate (1081836-51-2) → (E)-N’-((1-(2-hydroxyethyl)-1H-indol-4-yl)methylene)-2-(mesityloxy)acetohydrazide (1572183-90-4)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 16 h / 100 °C

2: dimethyl sulfoxide; acetic acid / 12 h / 20 °C

In ethanol; acetic acid; dimethyl sulfoxide;

upstream raw materials:

1H-indole-7-carbaldehyde

2-(mesitylamino)acetohydrazide

1-(2-hydroxyethyl)-1H-indol-4-carbaldehyde

2,4,6-trimethylbenzamide