4380-68-1

Basic information

• Product Name: 2,4,6-TRIMETHYL-BENZAMIDE
• Synonyms: 2,4,6-TRIMETHYL-BENZAMIDE;Benzamide, 2,4,6-trimethyl- (6CI,7CI,8CI,9CI)
• CAS NO: 4380-68-1
• Molecular Formula: C₁₀H₁₃NO
• Molecular Weight: 163.22
• Product Categories: AMIDE
• Mol File: 4380-68-1.mol

Chemical Properties

• Boiling Point: 231°C at 760 mmHg
• Flash Point: 93.5°C
• Appearance: /
• Density: 1.039g/cm³
• Vapor Pressure: 0.0639mmHg at 25°C
• Refractive Index: 1.545
• CAS DataBase Reference: 2,4,6-TRIMETHYL-BENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4,6-TRIMETHYL-BENZAMIDE(4380-68-1)
• EPA Substance Registry System: 2,4,6-TRIMETHYL-BENZAMIDE(4380-68-1)

Safety Data

• Hazardous Substances Data: 4380-68-1(Hazardous Substances Data)

Usage

Class

Benzamides

Derivative

Benzene

Usage

Building block in the synthesis of pharmaceuticals and agrochemicals, intermediate in the production of dyes and pigments

Physical form

White to off-white crystalline solid

Odor

Characteristic

Safety precautions

May cause skin and eye irritation, prolonged exposure can lead to adverse health effects

InChI:InChI=1/C10H13NO/c1-6-4-7(2)9(10(11)12)8(3)5-6/h4-5H,1-3H3,(H2,11,12)

Upstream product

• 480-63-7 mesitylenecarboxylic acid 
• 79137-73-8 N-Mesitoyl-α-(2-cyanethyl)-L-isoleucin 
• 79137-72-7 N-Mesitoyl-α-(3-oxobutyl)-L-isoleucin 
• 79137-83-0 N-Mesitoyl-α-(3-oxohexyl)phenylalanin 
• 412022-17-4 2,2,2-trichloro-1-mesityl-ethanone-imine 
• 60-29-7 diethyl ether 
• 7664-41-7 ammonia 
• 127099-85-8 N-Cyanoguanidine 
• 108-67-8 1,3,5-trimethyl-benzene 
• 79137-76-1 N-Mesitoyl-α-(1-methyl-3-oxobutyl)leucin 
• 79137-74-9 N-Mesitoyl-α-(3-oxobutyl)leucin 
• 79137-80-7 N-Mesitoyl-α-(2-cyanethyl)leucin 
• 79137-70-5 N-Mesitoyl-α-(3-oxobutyl)valin 
• 67-56-1 methanol 

Downstream Products

• 2571-52-0 cyanomesitylene 
• 16404-66-3 4-hydroxy-2,4,6-trimethyl-cyclohexa-2,5-dienone 
• 1572183-90-4 (E)-N’-((1-(2-hydroxyethyl)-1H-indol-4-yl)methylene)-2-(mesityloxy)acetohydrazide 
• 1572183-75-5 (E)-N’-((1H-indol-4-yl)methylene)-2-(mesitylamino)acetohydrazide 
• 1572183-74-4 (E)-N’-((1H-indol-4-yl)methylene)-2-(mesitylamino)acetohydrazide 
• 750624-66-9 2-(mesitylamino)acetohydrazide 
• 1081836-51-2 methyl 2-(mesitylamino)acetate 

Relevant articles and documents

Steric effects of polymethylcarboranes. Unusual reactivity of N-(deca-B-methyl-1,12-dicarba-closo-dodecaborane-1-carbonyl)pyridinium

Reaction of deca-B-methyl-1,12-dicarba-closo-dodecaborane-1-carbonyl chloride with aniline in pyridine gives predominantly deca-B-methyl-1,12-dicarba-closo-dodecaborane-1-carboxamide, accompanied by a small amount of the expected anilide. The results may be interpreted in terms of nucleophilic attack of aniline at the 2'-position of the N-(deca-B-methyl-1,12-dicarba-closo-dodecaborane-1-carbonyl)pyridinium intermediate, followed by ring-opening of the pyridine nucleus and recyclization.

A novel oxidative procedure for the synthesis of benzamides from styrenes and amines under metal-free conditions

An interesting procedure for the oxidative synthesis of amides from styrenes and amines has been developed. Various primary amides were formed in moderate yields (25-81%). Secondary amides can be produced in moderate yields as well (41-68%). Notably, no transition metal catalyst was needed for this transformation. This is the first example of oxidative transformation of styrenes to benzamides. This journal is the Partner Organisations 2014.

Benzamide synthesis by direct electrophilic aromatic substitution with cyanoguanidine

Cyanoguanidine is an inexpensive commodity chemical and it is found to be a useful reagent for the direct Friedel-Crafts carboxamidation of arenes. The reaction works best in an excess of Bronsted superacid, an observation suggesting the involvement of a superelectrophilic intermediate. Theoretical calculations indicate that the most stable diprotonated species involves protonation at the guanidine and cyano nitrogen atoms.

Facile and highly selective conversion of nitriles to amides via indirect acid-catalyzed hydration using TFA or AcOH-H2SO4

(Chemical Equation Presented) Both aliphatic and aromatic nitriles are conveniently and selectively converted in a single step, via an indirect acid-catalyzed hydration, into the corresponding amides in 1-8 h using a TFA-H2SO4 mixture as a reagent system. Although the same reagent did not work for the sterically hindered nitriles such as mesitonitrile, the transformation could be accomplished by changing TFA to AcOH at higher temperatures (>90°C).

On the Nature of Resonance Interactions in Substituted Benzenes. Part 3. A 13C Nuclear Magnetic Resonance Study of Substituent Effects in 4-Substituted Benzamides and Methyl Benzoates in Dimethyl sulphoxide

The substituent effect on the carbonyl-carbon chemical shift in 4-X-benzamides 2 and in 2,6-dimethyl-4-X-benzamides 2' has been studied in (CD3)2SO.Comparison of the results with those obtained from the corresponding methyl 4-X-benzoates 1 and 1'in the sa

Efficient Generation and Use of 3-carboalkoxycyclopentadienone as a Diels-Alder Dienophile

Treatment of benzyl 4-oxo-1-(phenylsulfonyl)cyclopent-2-ene-1-carboxylate (11) with amine base provides in situ generation of the cyclopentadienone moiety which has been shown to react with various dienes.Reaction temperature decreases up to 100 deg C wer

α-Aminosaeuren als nucleophile Acylaequivalente, V. Sterisch gelenkte Michael-Addition von Oxazolin-5-on-Anionen an aktivierte Doppelbindungen; Synthese von 1,4-Dicarbonylverbindungen und γ-Oxonitrilen

Oxazolin-5-ones with bulky substituents like mesityl or 1-butylcyclohexyl at C-2 undergo triethylamine catalyzed addition to activated olefins exclusively at C-4.Hydrolysis of the derived 4,4-disubstituted 2-mesityl-2-oxazolin-5-ones 9 leads to N-mesitoyl