methyl N-{4-[4-(biphenyl-4-carbonyl)piperazin-1-yl]-6-ethylthieno[2,3-c]pyrimidin-2-yl}succinamate

Base Information

Chemical Name:methyl N-{4-[4-(biphenyl-4-carbonyl)piperazin-1-yl]-6-ethylthieno[2,3-c]pyrimidin-2-yl}succinamate
CAS No.:911214-83-0
Molecular Formula:C₃₀H₃₁N₅O₄S
Molecular Weight:557.673
Hs Code.:

Synonyms:methyl N-{4-[4-(biphenyl-4-carbonyl)piperazin-1-yl]-6-ethylthieno[2,3-c]pyrimidin-2-yl}succinamate

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Chemical Property of methyl N-{4-[4-(biphenyl-4-carbonyl)piperazin-1-yl]-6-ethylthieno[2,3-c]pyrimidin-2-yl}succinamate

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Technology Process of methyl N-{4-[4-(biphenyl-4-carbonyl)piperazin-1-yl]-6-ethylthieno[2,3-c]pyrimidin-2-yl}succinamate

There total 7 articles about methyl N-{4-[4-(biphenyl-4-carbonyl)piperazin-1-yl]-6-ethylthieno[2,3-c]pyrimidin-2-yl}succinamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 911214-76-1
4-[4-(1,1'-biphenyl-4-ylcarbonyl)piperazin-1-yl]-6-ethylthieno[2,3-d]pyrimidin-2-amine

: 1490-25-1
succinic acid monomethylester chloride

: 911214-83-0
methyl N-{4-[4-(biphenyl-4-carbonyl)piperazin-1-yl]-6-ethylthieno[2,3-c]pyrimidin-2-yl}succinamate

Guidance literature:: With pyridine; at 20 ℃; for 3.16h;

Reference yield:

: 502644-41-9
tert-butyl 4-(2-chloro-6-ethylthieno[2,3-d]pyrimidin-4-yl)-piperazine-1-carboxylate

: 911214-83-0
methyl N-{4-[4-(biphenyl-4-carbonyl)piperazin-1-yl]-6-ethylthieno[2,3-c]pyrimidin-2-yl}succinamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride / 1,4-dioxane / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 20 °C

3.1: sodium azide / 1-methyl-pyrrolidin-2-one; water / 20 - 132 °C

4.1: trimethylphosphane / tetrahydrofuran / 18 h / 20 °C

4.2: 1 h / 90 °C / Heating / reflux

5.1: pyridine / 3.16 h / 20 °C

With pyridine; hydrogenchloride; sodium azide; N-ethyl-N,N-diisopropylamine; trimethylphosphane; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; water; N,N-dimethyl-formamide;

Reference yield:

: 502649-08-3
6-ethylthieno[2,3-d]pyrimidine-2,4-diol

: 911214-83-0
methyl N-{4-[4-(biphenyl-4-carbonyl)piperazin-1-yl]-6-ethylthieno[2,3-c]pyrimidin-2-yl}succinamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: trichlorophosphate / 1.5 h / 150 °C

2.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 6 h / 20 °C

3.1: hydrogenchloride / 1,4-dioxane / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 20 °C

5.1: sodium azide / 1-methyl-pyrrolidin-2-one; water / 20 - 132 °C

6.1: trimethylphosphane / tetrahydrofuran / 18 h / 20 °C

6.2: 1 h / 90 °C / Heating / reflux

7.1: pyridine / 3.16 h / 20 °C

With pyridine; hydrogenchloride; sodium azide; N-ethyl-N,N-diisopropylamine; trichlorophosphate; trimethylphosphane; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; water; N,N-dimethyl-formamide;