4-[4-(1,1'-biphenyl-4-ylcarbonyl)piperazin-1-yl]-6-ethylthieno[2,3-d]pyrimidin-2-amine

Base Information

Chemical Name:4-[4-(1,1'-biphenyl-4-ylcarbonyl)piperazin-1-yl]-6-ethylthieno[2,3-d]pyrimidin-2-amine
CAS No.:911214-76-1
Molecular Formula:C₂₅H₂₅N₅OS
Molecular Weight:443.572
Hs Code.:

Synonyms:4-[4-(1,1'-biphenyl-4-ylcarbonyl)piperazin-1-yl]-6-ethylthieno[2,3-d]pyrimidin-2-amine

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Chemical Property of 4-[4-(1,1'-biphenyl-4-ylcarbonyl)piperazin-1-yl]-6-ethylthieno[2,3-d]pyrimidin-2-amine

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Technology Process of 4-[4-(1,1'-biphenyl-4-ylcarbonyl)piperazin-1-yl]-6-ethylthieno[2,3-d]pyrimidin-2-amine

There total 7 articles about 4-[4-(1,1'-biphenyl-4-ylcarbonyl)piperazin-1-yl]-6-ethylthieno[2,3-d]pyrimidin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 911214-75-0
2-azido-4-[4-(1,1'-biphenyl-4-ylcarbonyl)piperazin-1-yl]-6-ethylthieno[2,3-d]pyrimidine

: 911214-76-1
4-[4-(1,1'-biphenyl-4-ylcarbonyl)piperazin-1-yl]-6-ethylthieno[2,3-d]pyrimidin-2-amine

Guidance literature:: 2-azido-4-[4-(1,1'-biphenyl-4-ylcarbonyl)piperazin-1-yl]-6-ethylthieno[2,3-d]pyrimidine; With trimethylphosphane; In tetrahydrofuran; at 20 ℃; for 18h;

With methanol; In tetrahydrofuran; at 90 ℃; for 1h; Heating / reflux;

Reference yield:

: 502644-41-9
tert-butyl 4-(2-chloro-6-ethylthieno[2,3-d]pyrimidin-4-yl)-piperazine-1-carboxylate

: 911214-76-1
4-[4-(1,1'-biphenyl-4-ylcarbonyl)piperazin-1-yl]-6-ethylthieno[2,3-d]pyrimidin-2-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride / 1,4-dioxane / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 20 °C

3.1: sodium azide / 1-methyl-pyrrolidin-2-one; water / 20 - 132 °C

4.1: trimethylphosphane / tetrahydrofuran / 18 h / 20 °C

4.2: 1 h / 90 °C / Heating / reflux

With hydrogenchloride; sodium azide; N-ethyl-N,N-diisopropylamine; trimethylphosphane; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; water; N,N-dimethyl-formamide;

Reference yield:

: 19156-63-9
2-amino-5-ethylthiophene-3-carboxylic acid methyl ester

: 911214-76-1
4-[4-(1,1'-biphenyl-4-ylcarbonyl)piperazin-1-yl]-6-ethylthieno[2,3-d]pyrimidin-2-amine

Guidance literature:: Multi-step reaction with 7 steps

1.1: acetic acid / water / 20 h / 20 °C

1.2: 2 h / Heating / reflux

1.3: 5 °C / pH 6

2.1: trichlorophosphate / 1.5 h / 150 °C

3.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 6 h / 20 °C

4.1: hydrogenchloride / 1,4-dioxane / 20 °C

5.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 20 °C

6.1: sodium azide / 1-methyl-pyrrolidin-2-one; water / 20 - 132 °C

7.1: trimethylphosphane / tetrahydrofuran / 18 h / 20 °C

7.2: 1 h / 90 °C / Heating / reflux

With hydrogenchloride; sodium azide; acetic acid; N-ethyl-N,N-diisopropylamine; trichlorophosphate; trimethylphosphane; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; water; N,N-dimethyl-formamide;