[(2R)-2-methyl-3-hydroxy-1-propyl][(1S)-1-(benzoylamino)-2-phenylethyl]diphenylsilane

Base Information

Chemical Name:[(2R)-2-methyl-3-hydroxy-1-propyl][(1S)-1-(benzoylamino)-2-phenylethyl]diphenylsilane
CAS No.:727726-48-9
Molecular Formula:C₃₁H₃₃NO₂Si
Molecular Weight:479.694
Hs Code.:

Synonyms:[(2R)-2-methyl-3-hydroxy-1-propyl][(1S)-1-(benzoylamino)-2-phenylethyl]diphenylsilane

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Chemical Property of [(2R)-2-methyl-3-hydroxy-1-propyl][(1S)-1-(benzoylamino)-2-phenylethyl]diphenylsilane

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Technology Process of [(2R)-2-methyl-3-hydroxy-1-propyl][(1S)-1-(benzoylamino)-2-phenylethyl]diphenylsilane

There total 9 articles about [(2R)-2-methyl-3-hydroxy-1-propyl][(1S)-1-(benzoylamino)-2-phenylethyl]diphenylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.5%

: 727726-46-7
[(2R)-2-methyl-3-(phenylmethoxy)-1-propyl][1-(benzoylamino)-2-phenylethyl]diphenylsilane

: 727726-47-8
[(2R)-2-methyl-3-hydroxy-1-propyl][(1R)-1-(benzoylamino)-2-phenylethyl]diphenylsilane

: 727726-48-9
[(2R)-2-methyl-3-hydroxy-1-propyl][(1S)-1-(benzoylamino)-2-phenylethyl]diphenylsilane

Guidance literature:: With boron tribromide; In dichloromethane; at -78 - 20 ℃; for 5h;
DOI:10.1021/jo048121v

Reference yield:

: 312-40-3
difluorodiphenylsilane

: 727726-48-9
[(2R)-2-methyl-3-hydroxy-1-propyl][(1S)-1-(benzoylamino)-2-phenylethyl]diphenylsilane

Guidance literature:: Multi-step reaction with 8 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 1.25 h / 0 °C

1.2: 83 percent / tetrahydrofuran; hexane / -78 - 20 °C

2.1: tert-butyllithium / pentane; diethyl ether / 0.83 h / -78 - 20 °C

2.2: 65 percent / diethyl ether; pentane / -78 - 20 °C

3.1: 73 percent / HgCl₂; water / acetonitrile / 1.25 h / 20 °C

4.1: 100 percent / LiAlH₄ / diethyl ether / 3 h / 0 - 20 °C

5.1: 63 percent / triphenylphosphine; diethyl azodicarboxylate / tetrahydrofuran / 24 h / 20 °C

6.1: hydrazine / ethanol / 6 h / Heating

7.1: 117 mg / NaHCO₃ / diethyl ether; H₂O / 1.5 h

8.1: 49.5 percent / boron tribromide / CH₂Cl₂ / 5 h / -78 - 20 °C

With lithium aluminium tetrahydride; n-butyllithium; water; tert.-butyl lithium; boron tribromide; sodium hydrogencarbonate; triphenylphosphine; mercury dichloride; hydrazine; diethylazodicarboxylate; In tetrahydrofuran; diethyl ether; ethanol; hexane; dichloromethane; water; acetonitrile; pentane;
DOI:10.1021/jo048121v

Reference yield:

: 31593-52-9
2-benzyl-1,3-dithiane

: 727726-48-9
[(2R)-2-methyl-3-hydroxy-1-propyl][(1S)-1-(benzoylamino)-2-phenylethyl]diphenylsilane

Guidance literature:: Multi-step reaction with 8 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 1.25 h / 0 °C

1.2: 83 percent / tetrahydrofuran; hexane / -78 - 20 °C

2.1: tert-butyllithium / pentane; diethyl ether / 0.83 h / -78 - 20 °C

2.2: 65 percent / diethyl ether; pentane / -78 - 20 °C

3.1: 73 percent / HgCl₂; water / acetonitrile / 1.25 h / 20 °C

4.1: 100 percent / LiAlH₄ / diethyl ether / 3 h / 0 - 20 °C

5.1: 63 percent / triphenylphosphine; diethyl azodicarboxylate / tetrahydrofuran / 24 h / 20 °C

6.1: hydrazine / ethanol / 6 h / Heating

7.1: 117 mg / NaHCO₃ / diethyl ether; H₂O / 1.5 h

8.1: 49.5 percent / boron tribromide / CH₂Cl₂ / 5 h / -78 - 20 °C

With lithium aluminium tetrahydride; n-butyllithium; water; tert.-butyl lithium; boron tribromide; sodium hydrogencarbonate; triphenylphosphine; mercury dichloride; hydrazine; diethylazodicarboxylate; In tetrahydrofuran; diethyl ether; ethanol; hexane; dichloromethane; water; acetonitrile; pentane;
DOI:10.1021/jo048121v