(3-{[3-(2-ethoxy-3,4-dioxo-cyclobut-1-enylamino)-propyl]-methyl-amino}-propyl)-carbamic acid tert-butyl ester

Base Information

• Chemical Name: (3-{[3-(2-ethoxy-3,4-dioxo-cyclobut-1-enylamino)-propyl]-methyl-amino}-propyl)-carbamic acid tert-butyl ester
• CAS No.: 916728-41-1
• Molecular Formula: C₁₈H₃₁N₃O₅
• Molecular Weight: 369.461
• Mol file: 916728-41-1.mol

Synonyms:(3-{[3-(2-ethoxy-3,4-dioxo-cyclobut-1-enylamino)-propyl]-methyl-amino}-propyl)-carbamic acid tert-butyl ester

Chemical Property of (3-{[3-(2-ethoxy-3,4-dioxo-cyclobut-1-enylamino)-propyl]-methyl-amino}-propyl)-carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3-{[3-(2-ethoxy-3,4-dioxo-cyclobut-1-enylamino)-propyl]-methyl-amino}-propyl)-carbamic acid tert-butyl ester

There total 3 articles about (3-{[3-(2-ethoxy-3,4-dioxo-cyclobut-1-enylamino)-propyl]-methyl-amino}-propyl)-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

N-(3-aminopropyl)-N-(3-tert-butyloxycarbonyl-aminopropyl)-N-methylamine (87530-14-1) + 3,4-diethoxy-3-cyclobuten-1,2-dione (5231-87-8) → (3-{[3-(2-ethoxy-3,4-dioxo-cyclobut-1-enylamino)-propyl]-methyl-amino}-propyl)-carbamic acid tert-butyl ester (916728-41-1)

Guidance literature:

In diethyl ether; at 20 ℃; for 12h;

DOI:10.1002/anie.200602790

Reference yield:

3,3'-Diamino-N-methyldipropylamine (105-83-9) → (3-{[3-(2-ethoxy-3,4-dioxo-cyclobut-1-enylamino)-propyl]-methyl-amino}-propyl)-carbamic acid tert-butyl ester (916728-41-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 74 percent / dioxane / 4 h / Heating

2: 72 percent / diethyl ether / 12 h / 20 °C

In 1,4-dioxane; diethyl ether;

DOI:10.1002/anie.200602790

Reference yield:

2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile (58632-95-4) → (3-{[3-(2-ethoxy-3,4-dioxo-cyclobut-1-enylamino)-propyl]-methyl-amino}-propyl)-carbamic acid tert-butyl ester (916728-41-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 74 percent / dioxane / 4 h / Heating

2: 72 percent / diethyl ether / 12 h / 20 °C

In 1,4-dioxane; diethyl ether;

DOI:10.1002/anie.200602790

upstream raw materials:

N-(3-aminopropyl)-N-(3-tert-butyloxycarbonyl-aminopropyl)-N-methylamine

3,4-diethoxy-3-cyclobuten-1,2-dione

3,3'-Diamino-N-methyldipropylamine

2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile

Downstream raw materials:

C₄₅H₇₃N₉O₈

C₆₇H₁₀₇N₁₅O₁₂

C₆₁H₁₀₃N₁₅O₁₂

C₅₀H₈₆N₁₂O₁₀