2-Fluoro-3-methylphenylboronic acid

Base Information

• Chemical Name: 2-Fluoro-3-methylphenylboronic acid
• CAS No.: 762287-58-1
• Molecular Formula: C₇H₈BFO₂
• Molecular Weight: 153.949
• Hs Code.: 2931900090
• European Community (EC) Number: 687-895-7
• DSSTox Substance ID: DTXSID70585935
• Wikidata: Q72474774
• Mol file: 762287-58-1.mol

Synonyms:2-Fluoro-3-methylphenylboronic acid;762287-58-1;(2-Fluoro-3-methylphenyl)boronic acid;2-Fluoro-3-methylbenzeneboronic acid;2-FLUORO-3-TOLYLBORONIC ACID;2-FLUORO-3-TOLYLBORONICACID;(2-Fluoro-3-methyl-phenyl)boronic acid;3-Borono-2-fluorotoluene;SCHEMBL698883;DTXSID70585935;VEHQHYJZLSODOU-UHFFFAOYSA-N;MFCD06409950;(2-Fluoro-3-methylphenyl)boronicacid;2-fluoro-3-methyl-phenylboronic acid;AKOS006344217;AB23826;AM87185;AS-18757;B-(2-Fluoro-3-methylphenyl)boronic acid;A9661;CS-0113029;I12054;2-Fluoro-3-methylphenylboronic acid, AldrichCPR;EN300-7009442;J-519651;Z1201623506

Chemical Property of 2-Fluoro-3-methylphenylboronic acid

Chemical Property:

• Vapor Pressure: 0.000947mmHg at 25°C
• Melting Point: 160-161℃
• Refractive Index: 1.505
• Boiling Point: 290.5 °C at 760 mmHg
• PKA: 8.42±0.58(Predicted)
• Flash Point: 129.5 °C
• PSA: 40.46000
• Density: 1.2 g/cm³
• LogP: -0.18610
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 154.0601378
• Heavy Atom Count: 11
• Complexity: 132

Purity/Quality:

99% ^*data from raw suppliers

2-Fluoro-3-methylphenylboronicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 37/38-41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: B(C1=C(C(=CC=C1)C)F)(O)O

Technology Process of 2-Fluoro-3-methylphenylboronic acid

There total 1 articles about 2-Fluoro-3-methylphenylboronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

2-Fluorotoluene (95-52-3) → (2-fluoro-3-methylphenyl)boronic acid (762287-58-1)

Guidance literature:

2-Fluorotoluene; With n-butyllithium; potassium tert-butylate; In tetrahydrofuran; hexane; at -78 ℃; for 2h; Inert atmosphere;

With Triisopropyl borate; In tetrahydrofuran; hexane; at -78 - 20 ℃;

With hydrogenchloride; In tetrahydrofuran; hexane; water; pH=1;

DOI:10.1016/j.tet.2010.05.014

Reference yield:

5-bromo-3-iodo-1-(4-methylbenzene-1-sulfonyl)-1H-pyrrolo[2,3-b]pyridine (875639-15-9) + (2-fluoro-3-methylphenyl)boronic acid (762287-58-1) → C21H16BrFN2O2S

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate; In acetonitrile; at 90 ℃; for 18h; Inert atmosphere; Sealed tube;

Reference yield:

(2-fluoro-3-methylphenyl)boronic acid (762287-58-1) → N-(3-(3-(2-fluoro-3-methylphenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)acrylamide

Guidance literature:

Multi-step reaction with 4 steps

1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate / acetonitrile / 18 h / 90 °C / Inert atmosphere; Sealed tube

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate / acetonitrile / 18 h / 90 °C / Inert atmosphere; Sealed tube

3: potassium carbonate / methanol; water / 60 °C

4: triethylamine / dichloromethane / 0 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; caesium carbonate; triethylamine; In methanol; dichloromethane; water; acetonitrile;

upstream raw materials:

2-Fluorotoluene

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 762287-58-1 2-FLUORO-3-TOLYLBORONIC ACID

Send

Send

Metric Ton KG G Pound L ML

Send

Send