ethyl 1-<<2'-(aminocarbonyl)(1,1'-biphenyl)-4-yl>methyl>-2-butyl-4-(methylthio)-1H-imidazole-5-carboxylate

Base Information

Chemical Name:ethyl 1-<<2'-(aminocarbonyl)(1,1'-biphenyl)-4-yl>methyl>-2-butyl-4-(methylthio)-1H-imidazole-5-carboxylate
CAS No.:164412-97-9
Molecular Formula:C₂₅H₂₉N₃O₃S
Molecular Weight:451.59
Hs Code.:

Synonyms:ethyl 1-<<2'-(aminocarbonyl)(1,1'-biphenyl)-4-yl>methyl>-2-butyl-4-(methylthio)-1H-imidazole-5-carboxylate

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Chemical Property of ethyl 1-<<2'-(aminocarbonyl)(1,1'-biphenyl)-4-yl>methyl>-2-butyl-4-(methylthio)-1H-imidazole-5-carboxylate

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Technology Process of ethyl 1-<<2'-(aminocarbonyl)(1,1'-biphenyl)-4-yl>methyl>-2-butyl-4-(methylthio)-1H-imidazole-5-carboxylate

There total 8 articles about ethyl 1-<<2'-(aminocarbonyl)(1,1'-biphenyl)-4-yl>methyl>-2-butyl-4-(methylthio)-1H-imidazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-Butyl-3-(2'-chlorocarbonyl-biphenyl-4-ylmethyl)-5-methylsulfanyl-3H-imidazole-4-carboxylic acid ethyl ester

: 164412-97-9
ethyl 1-<<2'-(aminocarbonyl)(1,1'-biphenyl)-4-yl>methyl>-2-butyl-4-(methylthio)-1H-imidazole-5-carboxylate

Guidance literature:: With ammonium hydroxide; In 1,4-dioxane; for 0.5h; Yield given; Ambient temperature;
DOI:10.1021/jm00013a013

Reference yield:

: 638-29-9
n-valeryl chloride

: 164412-97-9
ethyl 1-<<2'-(aminocarbonyl)(1,1'-biphenyl)-4-yl>methyl>-2-butyl-4-(methylthio)-1H-imidazole-5-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: 75 percent / pyridine / CH₂Cl₂ / 0 °C

2: 87 percent / triethylamine / ethanol / 50 h / 0 °C

3: 72 percent / PCl₅, 4-(dimethylamino)pyridine / CH₂Cl₂ / 12 h / Ambient temperature

4: 68 percent / K₂CO₃ / dimethylformamide / 45 h / 20 - 25 °C

5: 85 percent / CF₃COOH / CH₂Cl₂ / 6 h / Ambient temperature

6: thionyl chloride / 4 h / Heating

7: 22percent NH₄OH / dioxane / 0.5 h / Ambient temperature

With pyridine; dmap; ammonium hydroxide; thionyl chloride; phosphorus pentachloride; potassium carbonate; triethylamine; trifluoroacetic acid; In 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00013a013

Reference yield:

: 139742-83-9
ethyl 2-cyano-2-n-butylcarbonylaminoacetate

: 164412-97-9
ethyl 1-<<2'-(aminocarbonyl)(1,1'-biphenyl)-4-yl>methyl>-2-butyl-4-(methylthio)-1H-imidazole-5-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: 87 percent / triethylamine / ethanol / 50 h / 0 °C

2: 72 percent / PCl₅, 4-(dimethylamino)pyridine / CH₂Cl₂ / 12 h / Ambient temperature

3: 68 percent / K₂CO₃ / dimethylformamide / 45 h / 20 - 25 °C

4: 85 percent / CF₃COOH / CH₂Cl₂ / 6 h / Ambient temperature

5: thionyl chloride / 4 h / Heating

6: 22percent NH₄OH / dioxane / 0.5 h / Ambient temperature

With dmap; ammonium hydroxide; thionyl chloride; phosphorus pentachloride; potassium carbonate; triethylamine; trifluoroacetic acid; In 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00013a013