2-{4-chloro-3-[(2-chloro-4-{[(2S)-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl]methoxy}benzoyl)amino]phenyl}-2-methylpropanoic acid

Base Information

Chemical Name:2-{4-chloro-3-[(2-chloro-4-{[(2S)-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl]methoxy}benzoyl)amino]phenyl}-2-methylpropanoic acid
CAS No.:848846-58-2
Molecular Formula:C₂₇H₂₆Cl₂N₂O₅
Molecular Weight:529.42
Hs Code.:

Synonyms:2-{4-chloro-3-[(2-chloro-4-{[(2S)-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl]methoxy}benzoyl)amino]phenyl}-2-methylpropanoic acid

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Chemical Property of 2-{4-chloro-3-[(2-chloro-4-{[(2S)-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl]methoxy}benzoyl)amino]phenyl}-2-methylpropanoic acid

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Technology Process of 2-{4-chloro-3-[(2-chloro-4-{[(2S)-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl]methoxy}benzoyl)amino]phenyl}-2-methylpropanoic acid

There total 6 articles about 2-{4-chloro-3-[(2-chloro-4-{[(2S)-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl]methoxy}benzoyl)amino]phenyl}-2-methylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: methyl 2-(4-chloro-3-((2-chloro-4-(((2S)-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl)methoxy)benzoyl)amino)phenyl)-2-methylpropanoate

: 848846-58-2
2-{4-chloro-3-[(2-chloro-4-{[(2S)-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl]methoxy}benzoyl)amino]phenyl}-2-methylpropanoic acid

Guidance literature:: methyl 2-(4-chloro-3-((2-chloro-4-(((2S)-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl)methoxy)benzoyl)amino)phenyl)-2-methylpropanoate; With methanol; sodium hydroxide; water; In tetrahydrofuran; at 50 ℃; for 4h;

With hydrogenchloride; methanol; water; In tetrahydrofuran;

Reference yield:

: 178556-45-1
2-(4-chloro-3-nitrophenyl)-2-methylpropanoic acid

: 848846-58-2
2-{4-chloro-3-[(2-chloro-4-{[(2S)-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl]methoxy}benzoyl)amino]phenyl}-2-methylpropanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: thionyl chloride / 1,2-dimethoxyethane / 4 h / 0 - 40 °C

2: 20 % Pd(OH)2/C; hydrogen / dimethyl sulfoxide; ethyl acetate / 5 h / 20 °C

3: pyridine / dichloromethane / 20 °C

4: sodium hydroxide / 1,4-dioxane; methanol; water / 2 h / 20 °C

With pyridine; thionyl chloride; 20 % Pd(OH)2/C; hydrogen; sodium hydroxide; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; dichloromethane; water; dimethyl sulfoxide; ethyl acetate;
DOI:10.1016/j.bmc.2011.08.065

Reference yield:

: 343326-75-0
methyl 2-(4-chloro-3-nitrophenyl)-2-methylpropanoate

: 848846-58-2
2-{4-chloro-3-[(2-chloro-4-{[(2S)-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl]methoxy}benzoyl)amino]phenyl}-2-methylpropanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 20 % Pd(OH)2/C; hydrogen / dimethyl sulfoxide; ethyl acetate / 5 h / 20 °C

2: pyridine / dichloromethane / 20 °C

3: sodium hydroxide / 1,4-dioxane; methanol; water / 2 h / 20 °C

With pyridine; 20 % Pd(OH)2/C; hydrogen; sodium hydroxide; In 1,4-dioxane; methanol; dichloromethane; water; dimethyl sulfoxide; ethyl acetate;
DOI:10.1016/j.bmc.2011.08.065