2-cyano-N-(4-{[(5-methylisoxazol-3-yl)amino]sulfonyl}phenyl)-3,3-bis(methylthio)acrylamide

Base Information

Chemical Name:2-cyano-N-(4-{[(5-methylisoxazol-3-yl)amino]sulfonyl}phenyl)-3,3-bis(methylthio)acrylamide
CAS No.:1627963-10-3
Molecular Formula:C₁₆H₁₆N₄O₄S₃
Molecular Weight:424.525
Hs Code.:

Synonyms:2-cyano-N-(4-{[(5-methylisoxazol-3-yl)amino]sulfonyl}phenyl)-3,3-bis(methylthio)acrylamide

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Chemical Property of 2-cyano-N-(4-{[(5-methylisoxazol-3-yl)amino]sulfonyl}phenyl)-3,3-bis(methylthio)acrylamide

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Technology Process of 2-cyano-N-(4-{[(5-methylisoxazol-3-yl)amino]sulfonyl}phenyl)-3,3-bis(methylthio)acrylamide

There total 2 articles about 2-cyano-N-(4-{[(5-methylisoxazol-3-yl)amino]sulfonyl}phenyl)-3,3-bis(methylthio)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 75-15-0,12122-00-8
carbon disulfide

: 901373-59-9
2-cyano-N-(4-{[(5-methylisoxazol-3-yl)amino]sulfonyl}phenyl)acetamide

: 77-78-1
dimethyl sulfate

: 1627963-10-3
2-cyano-N-(4-{[(5-methylisoxazol-3-yl)amino]sulfonyl}phenyl)-3,3-bis(methylthio)acrylamide

Guidance literature:: carbon disulfide; 2-cyano-N-(4-{[(5-methylisoxazol-3-yl)amino]sulfonyl}phenyl)acetamide; With potassium hydroxide; In N,N-dimethyl-formamide; at 10 ℃; for 2h;

dimethyl sulfate; In N,N-dimethyl-formamide; at 15 ℃; for 1h;
DOI:10.3987/COM-14-12954

Reference yield:

: 723-46-6
sulfamethoxazole

: 1627963-10-3
2-cyano-N-(4-{[(5-methylisoxazol-3-yl)amino]sulfonyl}phenyl)-3,3-bis(methylthio)acrylamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1,4-dioxane / 3 h / Reflux

2.1: potassium hydroxide / N,N-dimethyl-formamide / 2 h / 10 °C

2.2: 1 h / 15 °C

With potassium hydroxide; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.3987/COM-14-12954